Jensen F E, Holmes G L, Lombroso C T, Blume H K, Firkusny I R
Department of Neurology, Children's Hospital, Boston, Massachusetts 02115.
Epilepsia. 1992 Nov-Dec;33(6):971-80. doi: 10.1111/j.1528-1157.1992.tb01746.x.
We showed that hypoxia is acutely epileptogenic in immature but not in adult rats. In the present study, we evaluated whether hypoxia results in an increase in long-term seizure susceptibility to flurothyl and whether this is associated with impaired performance on behavioral tests. We also determined whether these long-term outcomes are dependent on age at time of O2 deprivation. Long Evans hooded rats were rendered hypoxic on either postnatal day (P)5, P10, or P60. Sixty to 75 days after hypoxia, rats were tested for performance in water maze, open field, and handling tests and for seizure susceptibility to flurothyl. Hypoxia at P10 significantly increased seizure susceptibility to flurothyl, whereas hypoxia at P5 and P60 induced no long-term changes in seizure threshold. At P10, greater seizure severity during hypoxia and more prolonged exposure to hypoxia significantly increased long-term seizure susceptibility. This long-term change in seizure susceptibility appeared to be dissociated from any long-term neurobehavioral consequences, because only animals rendered hypoxic as adults (P60) had impaired behavioral performance. The results suggest that hypoxia-induced seizures can alter long-term seizure susceptibility and that this long-term effect is dependent on age and on severity of seizure activity at the time of previous hypoxia.
我们发现，低氧在幼鼠中具有急性致痫性，而在成年大鼠中则不然。在本研究中，我们评估了低氧是否会导致对氟烷的长期癫痫易感性增加，以及这是否与行为测试表现受损有关。我们还确定了这些长期结果是否取决于缺氧时的年龄。将Long Evans 戴帽大鼠在出生后第（P）5天、P10天或P60天进行低氧处理。低氧处理60至75天后，对大鼠进行水迷宫、旷场和处理测试的表现以及对氟烷的癫痫易感性测试。P10时的低氧显著增加了对氟烷的癫痫易感性，而P5和P60时的低氧未引起癫痫阈值的长期变化。在P10时，低氧期间更严重的癫痫发作和更长时间的低氧暴露显著增加了长期癫痫易感性。癫痫易感性的这种长期变化似乎与任何长期神经行为后果无关，因为只有成年时（P60）出现低氧的动物行为表现受损。结果表明，低氧诱导的癫痫发作可改变长期癫痫易感性，且这种长期效应取决于年龄和先前低氧时癫痫活动的严重程度。
