Benedetti Enrico, Panaro Fabrizio, Holterman Mark, Abcarian Herand
University of Illinois at chicago, 1Division of Transplantation, 840 S. Wood St., Chicago, IL 60612, USA.
Best Pract Res Clin Gastroenterol. 2003 Dec;17(6):1017-40. doi: 10.1016/s1521-6918(03)00081-7.
The surgical treatment of short-bowel syndrome has been traditionally based on the correction of mechanical obstruction, which is responsible for bacterial overgrowth syndrome, or on intestinal expansion procedures. Since the introduction of clinical intestinal transplantation by Lillehei in 1964, there have been remarkable advances in the immunosuppressive regimens to control rejection and in preservation techniques, monitoring and critical care. Newer and more powerful immunosuppressants have helped to transform intestinal transplantation into a clinical reality-transplantation can now be a life-saving procedure for patients with intestinal failure. It is currently indicated in the event of life-threatening complications of an underlying disease or from total parenteral nutrition (TPN). Rehabilitation in successful cases is excellent.
短肠综合征的外科治疗传统上基于对导致细菌过度生长综合征的机械性肠梗阻的纠正，或基于肠道扩张手术。自1964年利尔黑开展临床肠道移植以来，在控制排斥反应的免疫抑制方案以及保存技术、监测和重症监护方面取得了显著进展。更新、更强效的免疫抑制剂已助力将肠道移植变为临床现实——如今，移植对于肠道衰竭患者而言可以是一种挽救生命的手术。目前，在潜在疾病或全胃肠外营养（TPN）出现危及生命的并发症时可考虑进行肠道移植。成功病例的康复情况良好。
