Life events, perceived stress and antibody response to influenza vaccination in young, healthy adults.
作者信息
Burns Victoria E, Carroll Douglas, Drayson Mark, Whitham Martin, Ring Christopher
机构信息
School of Sport and Exercise Sciences, University of Birmingham, B15 2TT, Birmingham, UK.
出版信息
J Psychosom Res. 2003 Dec;55(6):569-72. doi: 10.1016/s0022-3999(03)00073-4.
OBJECTIVES
Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect.
METHODS
Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective.
RESULTS
At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected.
CONCLUSIONS
Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.
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