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生物医学与农业领域的转基因动物:未来展望。

Transgenic animals in biomedicine and agriculture: outlook for the future.

作者信息

Wheeler M B, Walters E M, Clark S G

机构信息

366 Animal Sciences Laboratory, Department of Animal Sciences, University of Illinois at Urbana-Champaign, 1207 W. Gregory Dr., Urbana, IL 61801, USA.

出版信息

Anim Reprod Sci. 2003 Dec 15;79(3-4):265-89. doi: 10.1016/s0378-4320(03)00168-4.

Abstract

Transgenic animals are produced by introduction of 'foreign' deoxyribonucleic acid (DNA) into preimplantation embryos. The foreign DNA is inserted into the genetic material and may be expressed in tissues of the resulting individual. This technique is of great importance to many aspects of biomedical science including gene regulation, the immune system, cancer research, developmental biology, biomedicine, manufacturing and agriculture. The production of transgenic animals is one of a number of new and developing technologies that will have a profound impact on the genetic improvement of livestock. The rate at which these technologies are incorporated into production schemes will determine the speed at which we will be able to achieve our goal of more efficiently producing livestock, which meets consumer and market demand.

摘要

转基因动物是通过将“外源”脱氧核糖核酸(DNA)导入植入前胚胎而产生的。外源DNA被插入遗传物质中,并可能在由此产生的个体的组织中表达。这项技术对生物医学科学的许多方面都非常重要,包括基因调控、免疫系统、癌症研究、发育生物学、生物医学、制造业和农业。转基因动物的生产是众多新兴技术之一,这些技术将对家畜的遗传改良产生深远影响。这些技术被纳入生产方案的速度将决定我们能够实现更高效生产家畜这一目标的速度,而这一目标要满足消费者和市场需求。

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