Glanzer Jason G, Eberwine James H
Department of Pharmacology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.
Neurobiol Aging. 2003 Dec;24(8):1105-11. doi: 10.1016/j.neurobiolaging.2003.04.006.
Synaptogenesis and synaptic plasticity demonstrate the ability of neurons to mature and respond to various stimuli. Both of these events require protein synthesis, in particular, localized translation within dendrites. Dendrites localize specific mRNAs in proximity to dendritic spines and have the capacity to actively translate these mRNAs within various 'hotspots' in the dendritic space. Rates of dendritic translation are stimulated and inhibited by various agents, suggesting that several signaling pathways that modulate localized protein synthesis may exist within the dendrite. This review will cover several suggested pathways for regulation of dendritic translation and propose a correlation between deregulated dendritic translation and disease.
突触发生和突触可塑性体现了神经元成熟并对各种刺激做出反应的能力。这两个过程都需要蛋白质合成，特别是树突内的局部翻译。树突将特定的信使核糖核酸定位在树突棘附近，并能够在树突空间的各个“热点”内积极翻译这些信使核糖核酸。树突翻译的速率受到各种因素的刺激和抑制，这表明树突内可能存在几种调节局部蛋白质合成的信号通路。本综述将涵盖几种关于树突翻译调控的建议通路，并提出失调的树突翻译与疾病之间的关联。
