Korecky B, Rakusan K
Am J Physiol. 1978 Feb;234(2):H123-8. doi: 10.1152/ajpheart.1978.234.2.H123.
The length and width of enzymatically isolated individual rat cardiac myocytes were concurrently measured during normal and stimulated cardiac growth. In normal rats weighing between 75 and 750 g the length and width increased by 64 and 68% while their ratio remained constant (ca. 5.3). The cell volume, calculated on the basis of a cylindrical model, increased almost 5 times. The rates of increase in the volume of an average myocyte and in left ventricular mass were found to be similar, indicating that normal myocardial growth could be explained by hypertrophy of existing myocytes and no proliferation would be required. In cardiomegaly induced by aortic constriction in the adult rat, an increase in cell volume was observed while no significant changes in the length-to-width ratios could be detected. The cell volumes of the hypertrophic hearts corresponded to those observed in hearts of similar weight obtained from larger normal rats and the stimulated cardiac growth could also be explained solely by hypertrophy of existing cells.
在正常和刺激的心脏生长过程中，同时测量了酶分离的单个大鼠心肌细胞的长度和宽度。在体重75至750克的正常大鼠中，长度和宽度分别增加了64%和68%，而它们的比例保持恒定（约为5.3）。根据圆柱模型计算的细胞体积增加了近5倍。发现平均心肌细胞体积的增加速率与左心室质量的增加速率相似，这表明正常心肌生长可以用现有心肌细胞的肥大来解释，而不需要增殖。在成年大鼠主动脉缩窄诱导的心脏肥大中，观察到细胞体积增加，而长宽比没有明显变化。肥大心脏的细胞体积与从较大正常大鼠获得的相似重量心脏中观察到的细胞体积相对应，刺激的心脏生长也可以仅用现有细胞的肥大来解释。
