Browning Kirsteen N
Department of Internal Medicine, University of Michigan, 6520 MSRB1, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0682, USA.
Curr Opin Pharmacol. 2003 Dec;3(6):613-7. doi: 10.1016/j.coph.2003.06.011.
A large body of evidence has demonstrated that vagal afferent neurones show non-uniform properties and that distinct neuronal populations can be identified within the nodose ganglia. Of particular interest is recent work illustrating the significant degree of plasticity displayed by vagal sensory neurones; alterations in vagal afferent neuronal excitability might be important in the development and maintenance of gastrointestinal pathological states. Although it is unclear whether such adaptations are mimicked centrally, recent studies suggest that tonic afferent vagal inputs act as a 'brake' on inputs to the dorsal motor nucleus of the vagus. It would be reasonable to assume, therefore, that plasticity in the excitability of vagal afferent neurones would have dramatic consequences for the regulation and modulation of gastrointestinal vago-vagal reflexes.
大量证据表明，迷走神经传入神经元具有非均匀特性，并且可以在结状神经节内识别出不同的神经元群体。特别值得关注的是最近的研究工作，这些研究表明迷走神经感觉神经元具有显著程度的可塑性；迷走神经传入神经元兴奋性的改变可能在胃肠道病理状态的发展和维持中起重要作用。尽管尚不清楚这种适应性是否在中枢被模拟，但最近的研究表明，迷走神经的紧张性传入输入对迷走神经背运动核的输入起到“刹车”作用。因此，可以合理地假设，迷走神经传入神经元兴奋性的可塑性将对胃肠道迷走-迷走反射的调节产生重大影响。
