Browning Kirsteen N, Mendelowitz David
Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor 48109, USA.
Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G8-14. doi: 10.1152/ajpgi.00322.2002.
To understand vago-vagal reflexes, one must have an appreciation of the events surrounding the encoding, integration, and central transfer of peripheral sensations by vagal afferent neurons. A large body of work has shown that vagal afferent neurons have nonuniform properties and that distinct subpopulations of neurons exist within the nodose ganglia. These sensory neurons display a considerable degree of plasticity; electrophysiological, pharmacological, and neurochemical properties have all been shown to alter after peripheral tissue injury. The validity of claims of selective recordings from populations of neurons activated by peripheral stimuli may be diminished, however, by the recent demonstration that stimulation of a subpopulation of nodose neurons can enhance the activity of unstimulated neuronal neighbors. To better understand the neurophysiological processes occurring after vagal afferent stimulation, it is essential that the electrophysiological, pharmacological, and neurochemical properties of nodose neurons are correlated with their sensory function or, at the very least, with their specific innervation target.
要理解迷走-迷走反射，必须了解迷走神经传入神经元对外周感觉进行编码、整合及中枢传递的相关过程。大量研究表明，迷走神经传入神经元具有非均匀特性，且在结状神经节内存在不同的神经元亚群。这些感觉神经元表现出相当程度的可塑性；电生理、药理和神经化学特性在周围组织损伤后均已显示会发生改变。然而，最近有证据表明，刺激结状神经元亚群可增强未受刺激的相邻神经元的活动，这可能会削弱关于从外周刺激激活的神经元群体中进行选择性记录的说法的有效性。为了更好地理解迷走神经传入刺激后发生的神经生理过程，至关重要的是将结状神经元的电生理、药理和神经化学特性与其感觉功能相关联，或者至少与其特定的神经支配靶点相关联。
