Nouri-Mahdavi Kouros, Caprioli Joseph
Glaucoma Division, Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California 90095, USA.
Am J Ophthalmol. 2003 Dec;136(6):1001-8. doi: 10.1016/s0002-9394(03)00630-5.
To investigate the postoperative hypertensive phase (HP) in patients undergoing glaucoma drainage implant surgery.
Interventional case series.
A retrospective chart review of 156 consecutive eyes (139 patients) who underwent placement of an Ahmed Glaucoma Valve (AGV) with a follow-up of >or=3 months was performed. Main outcome measures were occurrence and resolution of the HP and intraocular pressure (IOP) control. The HP was defined as IOP > 21 mm Hg during the first 3 months after surgery. Resolution of the HP was defined as an IOP < 22 mm Hg and an IOP reduction of 3 mm Hg with the same or fewer number of glaucoma medications.
An HP was observed in 88 eyes (56%). It occurred after a mean of 5.0 weeks (median, 4 weeks; range, 1-13 weeks) with an average (+/- standard deviation) peak IOP of 30.1 (+/- 7.5) mm Hg. Resolution of the HP occurred in 19 of 68 eyes (28%) with available data. Eyes with an HP had a higher mean IOP and needed more medications 6 to 12 months after surgery than eyes without an HP (17.2 +/- 5.6 vs 14.3 +/- 5.8 mm Hg; P =.012 and 1.7 +/- 1.2 vs 0.3 +/- 0.6 medications; P <.001, respectively).
A hypertensive phase occurs frequently after implantation of the AGV. However, it resolves in only a minority of eyes. The majority of eyes with an HP have no significant improvement of IOP control and continue to require the same number of glaucoma medications as they did during the HP.
研究青光眼引流植入手术患者的术后高血压期(HP)。
干预性病例系列研究。
对156只连续眼(139例患者)进行回顾性病历审查,这些患者接受了艾哈迈德青光眼阀(AGV)植入术,随访时间≥3个月。主要观察指标为HP的发生与缓解情况以及眼压(IOP)控制情况。HP定义为术后前3个月内眼压>21 mmHg。HP缓解定义为眼压<22 mmHg且使用相同或更少数量的青光眼药物时眼压降低3 mmHg。
88只眼(56%)观察到HP。其平均发生时间为5.0周(中位数为4周;范围为1 - 13周),平均(±标准差)峰值眼压为30.1(±7.5)mmHg。在有可用数据的68只眼中,19只眼(28%)的HP得到缓解。有HP的眼在术后6至12个月的平均眼压更高,且比无HP的眼需要更多药物(分别为17.2±5.6 vs 14.3±5.8 mmHg;P = 0.012和1.7±1.2 vs 0.3±0.6种药物;P < 0.001)。
AGV植入术后高血压期频繁发生。然而,仅少数眼的HP会缓解。大多数有HP的眼眼压控制无明显改善,且继续需要与HP期间相同数量的青光眼药物。