6-氨基chrysene光产物的鉴定以及腐殖酸和核黄素对其光解作用的研究。
Identification of 6-aminochrysene photoproducts and study of the effect of a humic acid and riboflavin on its photolysis.
作者信息
Zeng Kui, Hwang Huey-min, Zhang Yi, Yu Hongtao
机构信息
Department of Biology, Jackson State University, Jackson, MS 39217, USA.
出版信息
J Photochem Photobiol B. 2003 Dec 5;72(1-3):95-100. doi: 10.1016/j.jphotobiol.2003.09.006.
The effect of the photosensitizer riboflavin (0, 10, 25, 50, 100 microM) and a river humic acid (0, 20, 40, 80 ppm) on the photolysis of 6-aminochrysene (6AC) in 10 mM PBS solution (pH 7.0) was studied. The presence of riboflavin significantly enhanced photolysis rate of 6AC. The photo-transformation half-life of 6AC was 1 or 36 min, respectively, in the presence or absence of riboflavin. The humic acid inhibited the photo-transformation rate of 6AC. The photo-transformation half-lives of 6AC were 37, 56, 92 min at 20, 40, 80 ppm humic acid, respectively. By using LC-MS, the main 6AC photoproduct identified was 5,6-chrysene-quinone along with some minor products. Both 6AC and 5,6-chrysene-quinone exhibited photoinduced cytotoxicity. A photochemical transformation pathway for 6AC was derived.
研究了光敏剂核黄素（0、10、25、50、100微摩尔）和河流腐殖酸（0、20、40、80 ppm）对10 mM PBS溶液（pH 7.0）中6-氨基chrysene（6AC）光解的影响。核黄素的存在显著提高了6AC的光解速率。在有或没有核黄素的情况下，6AC的光转化半衰期分别为1分钟或36分钟。腐殖酸抑制了6AC的光转化速率。在20、40、80 ppm腐殖酸条件下，6AC的光转化半衰期分别为37、56、92分钟。通过液相色谱-质谱联用，鉴定出的主要6AC光产物是5,6-chrysene-醌以及一些次要产物。6AC和5,6-chrysene-醌均表现出光诱导细胞毒性。推导了6AC的光化学转化途径。
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