Bublin J G, Thompson D F
College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City 73117.
J Clin Pharm Ther. 1992 Oct;17(5):297-302. doi: 10.1111/j.1365-2710.1992.tb01307.x.
Drug-induced hair colour changes are not a common adverse effect from medications. A wide variety of drugs have been implicated in causing hair colour changes but very few have data to support a true relationship. Of the drugs reported, chloroquine and cancer chemotherapeutic agents have the best evidence to support an association. Other drugs, such as p-aminobenzoic acid, calcium pantothenate, anthralin, chinoform, mephenesin, minoxidil, propofol, valproic acid, and verapamil await confirmatory data. Drug-induced causes should be considered in any patient with unexplained hair colour changes.
药物引起的头发颜色变化并非药物常见的不良反应。多种药物都被认为可能导致头发颜色改变，但只有极少数有数据支持这种真实关联。在已报道的药物中，氯喹和癌症化疗药物有最充分的证据支持存在这种关联。其他药物，如对氨基苯甲酸、泛酸钙、蒽林、氯碘喹啉、甲酚甘油醚、米诺地尔、丙泊酚、丙戊酸和维拉帕米，尚需确凿数据证实。任何出现不明原因头发颜色变化的患者都应考虑药物引起的原因。
