胎儿、新生儿及治疗变量对先天性甲状腺功能减退症患儿神经发育的差异影响。
Differential effect of fetal, neonatal and treatment variables on neurodevelopment in infants with congenital hypothyroidism.
作者信息
Alvarez M, Carvajal F, Renón A, Pérez C, Olivares A, Rodríguez G, Alvarez V
机构信息
Institute of Neurology and Neurosurgery, Havana, Cuba.
出版信息
Horm Res. 2004;61(1):17-20. doi: 10.1159/000075192. Epub 2003 Nov 27.
OBJECTIVES
To identify the influence of fetal, neonatal and treatment variables on neurodevelopment in children with congenital hypothyroidism.
METHODS
A multiple regression analysis was performed in the neurodevelopmental scores of 26 children with CH who were assessed at 3, 6, 12 and 18 months for postural control, fine eye-hand coordination and language. The independent variables were: duration of fetal hypothyroidism, initial biochemical severity, days at starting treatment, initial dose, and efficiency of treatment.
RESULTS
Postural control was predicted by duration of fetal hypothyroidism and language by the biochemical severity of the disease at birth. Fine eye-hand coordination was not predicted by any variable.
CONCLUSION
This pattern of influences suggests that fetal and neonatal hypothyroidism have different effects on brain maturation sites during the first 2 years of life and that some subtle neurocognitive deficits are probably unavoidable.
目的
确定胎儿、新生儿及治疗相关变量对先天性甲状腺功能减退症患儿神经发育的影响。
方法
对26例先天性甲状腺功能减退症患儿的神经发育评分进行多元回归分析，这些患儿在3、6、12和18个月时接受姿势控制、精细眼手协调和语言能力评估。自变量包括：胎儿甲状腺功能减退持续时间、初始生化严重程度、开始治疗天数、初始剂量及治疗效果。
结果
姿势控制由胎儿甲状腺功能减退持续时间预测，语言能力由出生时疾病的生化严重程度预测。精细眼手协调能力未由任何变量预测。
结论
这种影响模式表明，胎儿和新生儿甲状腺功能减退在生命的头两年对脑成熟部位有不同影响，一些细微的神经认知缺陷可能不可避免。
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