Edouard T, Trivin C, Lawson-Body E, Pinto G, Souberbielle J-C, Brauner R
Université René-Descartes and Pediatric Endocrinology Unit, Fondation Hôpital Saint-Joseph, Paris, France.
Horm Res. 2004;61(1):33-40. doi: 10.1159/000075195. Epub 2003 Nov 27.
The factors associated with lack of catch-up growth after intrauterine growth retardation (IUGR) are unknown.
To identify these factors by analyzing the clinical features and growth hormone (GH)-insulin-like growth factor I (IGF-I) axis.
95 patients with height <-3 SD after IUGR were assigned to group 1 without (n = 50) or group 2 with (n = 45) malformations. Twenty-one in group 1 and 19 in group 2 were treated with GH.
They were seen at 5.3 +/- 0.5 and 4 +/- 0.5 year (p = 0.02) with heights at -3.4 +/- 0.1 and -3.9 +/- 0.2 SD (p = 0.03). Group 1 differed from group 2 in having a lower frequency of consanguinity (2 vs. 28.9%, p < 0.001), and higher frequencies of target heights (26.5 vs. 6.7%, p = 0.02) and mothers' heights (34.7 vs. 8.9%, p < 0.01) <-2 SD, multiparity (26 vs. 8.9%, p < 0.05), prematurity (36 vs. 15.5%, p < 0.05) and cesarean section birth (42 vs. 17.8%, p = 0.01). The GH-IGF-I axis data and the height increases after 3 years of GH treatment (1.6 +/- 0.2 in group 1 and 1.1 +/- 0.3 SD in group 2) were similar.
The short height of the parents, particularly of the mother, is associated with factors limiting the catch-up growth after IUGR of children without malformations, while the high frequency of consanguinity in those with malformations suggests that transmitted fetal factors affect organogenesis or development.
宫内生长迟缓（IUGR）后缺乏追赶生长相关的因素尚不清楚。
通过分析临床特征和生长激素（GH）-胰岛素样生长因子I（IGF-I）轴来确定这些因素。
95例IUGR后身高<-3标准差的患者被分为1组（无畸形，n = 50）和2组（有畸形，n = 45）。1组21例和2组19例接受生长激素治疗。
他们分别在5.3±0.5岁和4±0.5岁时就诊（p = 0.02），身高分别为-3.4±0.1和-3.9±0.2标准差（p = 0.03）。1组与2组的区别在于近亲结婚频率较低（2%对28.9%，p<0.001），而目标身高（26.5%对6.7%，p = 0.02）和母亲身高（34.7%对8.9%，p<0.01）<-2标准差、多产（26%对8.9%，p<0.05）、早产（36%对15.5%，p<0.05）及剖宫产出生（42%对17.8%，p = 0.01）的频率较高。生长激素-胰岛素样生长因子I轴的数据以及生长激素治疗3年后的身高增长（1组为1.6±0.2，2组为1.1±0.3标准差）相似。
父母身材矮小，尤其是母亲身材矮小，与无畸形儿童IUGR后限制追赶生长的因素有关，而有畸形儿童中近亲结婚的高频率表明，传递的胎儿因素影响器官发生或发育。
