Blumer Kendall J, Cooper John A
Nat Cell Biol. 2003 Dec;5(12):1048-9. doi: 10.1038/ncb1203-1048.
Work in this issue advances our understanding of how the small G protein Cdc42 functions to polarize budding yeast. Remarkably, Cdc42 can polarize in the absence of upstream cues or positive feedback from the cytoskeleton. Polarization requires the scaffold protein Bem1 and cycling of Cdc42 between its GTP- and GDP-bound states.
本期的研究成果增进了我们对小G蛋白Cdc42如何使芽殖酵母极化的理解。值得注意的是，Cdc42在缺乏上游信号或细胞骨架的正反馈的情况下也能极化。极化需要支架蛋白Bem1以及Cdc42在其结合GTP和GDP状态之间的循环。
