Hilden Lori R, Morris Kenneth R
Bristol-Myers Squibb Company, PO Box 191, New Brunswick, New Jersey 08903-0191, USA.
J Pharm Sci. 2004 Jan;93(1):3-12. doi: 10.1002/jps.10489.
The physical state of a dosage form, crystalline versus amorphous, is critical in determining its solid-state physical and chemical properties. This minireview describes the physics associated with the preparation and storage of amorphous solids including a review of the common theories of the glass transition and relaxation processes.