Akopian Abram, Galoyan Armen
Department of Ophthalmology, New York University School of Medicine, New York, New York 10016, USA.
Neurochem Res. 2003 Dec;28(12):1867-71. doi: 10.1023/a:1026127909942.
Neurotrophins are molecules that regulate neuronal survival, nervous system plasticity, and many other physiological functions of neuronal and glial cells. Here we studied the physiological action of a novel neurosecretory polypeptide proline-rich polypeptide (PRP), isolated from bovine neurohypophysis neurosecretory granules, on voltage-gated Ca currents and spike firing activity of retinal ganglion cells. PRP reversibly increased high voltage-activated L-type Ca current, but was without effect on low voltage-activated T-type current. PRP also increased the spike after hyperpolarization and reduced the frequency of spike firing, most likely by affecting a Ca-dependent potassium current.
神经营养因子是一类调控神经元存活、神经系统可塑性以及神经元和神经胶质细胞许多其他生理功能的分子。在此，我们研究了一种从牛神经垂体神经分泌颗粒中分离出的新型神经分泌多肽——富含脯氨酸的多肽（PRP），对视网膜神经节细胞电压门控钙电流和动作电位发放活动的生理作用。PRP可逆性地增加高电压激活的L型钙电流，但对低电压激活的T型电流无影响。PRP还增加了超极化后的动作电位，并降低了动作电位发放频率，这很可能是通过影响一种钙依赖性钾电流实现的。
