Maniar S, Caldas A, Laouari D, Kleinknecht C
INSERM U-192, Hôpital Necker-Enfants Malades, Paris, France.
Miner Electrolyte Metab. 1992;18(2-5):241-4.
To determine what levels of chronic metabolic acidosis affect growth in uremia, we compared two groups of uremic rats receiving a 30% protein diet. This diet induced acidosis in A rats (n = 52; pH: 6.9-7.35) which was prevented by the addition of NaHCO3 in the diet of B rats (n = 52; pH: 7.38-7.46). A rats were separated into five groups by increasing severity of acidosis and were matched with B rats of similar renal function. Comparison between A and B rats showed: (1) no difference in food intake; (2) a reduction of weight gain only for severe acidosis with pH around 7.20 or less; (3) a reduction of length gain which was observed for less severe acidosis than reduction of weight gain, but which did not exist for marginal acidosis (pH > 7.25).
为了确定何种程度的慢性代谢性酸中毒会影响尿毒症患者的生长，我们比较了两组接受30%蛋白质饮食的尿毒症大鼠。这种饮食在A组大鼠（n = 52；pH值：6.9 - 7.35）中诱发了酸中毒，而在B组大鼠（n = 52；pH值：7.38 - 7.46）的饮食中添加NaHCO₃可预防酸中毒。根据酸中毒严重程度的增加，A组大鼠被分为五组，并与肾功能相似的B组大鼠进行匹配。A组和B组大鼠的比较显示：（1）食物摄入量无差异；（2）仅在pH值约为7.20或更低的严重酸中毒情况下体重增加减少；（3）身长增加减少，观察到该现象的酸中毒程度低于体重增加减少的程度，但在边缘性酸中毒（pH > 7.25）时不存在身长增加减少的情况。
