Sirimai Korakot, Sutchritpongsa Pavit, Chaisilwattana Pongsakdi, Laothong Kwanjit
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
J Med Assoc Thai. 2003 Oct;86(10):897-902.
The purpose of this prospective study was to determine the prevalence of human papillomavirus and abnormal Pap smear in HIV-seropositive women, particularly in HIV-seropositive women who undertook antiretroviral drug. The consecutive series of 178 HIV-seropositive women was enrolled in the Department of Obstetrics and Gynecology, Siriraj Hospital. All general information and laboratory results of the patients were recorded. Pap smears are obtained from the endocervix, cervical transformation zone and vagina by using a cotton tip stick and Ayre spatula, as described in the VCE technique. The patients were assigned into two groups, the AZT and non-AZT group. The comparison between the groups was calculated statistically. It was found that 88 of 178 HIV-seropositive women (49.4%) undertook Zidovudine. The prevalence of abnormal Pap smear in HIV-seropositive women, who had an abnormal Pap smear, was 59.6 per cent. However, the prevalence of human papillomavirus infection detected by Pap smear was reported in 17 patients (9.6%). There was no difference between the AZT and non-AZT group statistically. There was a significantly higher probability of finding an abnormal Pap smear for cervical dysplasia in HIV-seropositive women who were infected with human papillomavirus compared to. It is concluded that there is a higher risk of developing cervical dysplasia in HIV-seropositive women who carry the human papillomavirus.
这项前瞻性研究的目的是确定艾滋病毒血清阳性女性，尤其是接受抗逆转录病毒药物治疗的艾滋病毒血清阳性女性中人类乳头瘤病毒（HPV）的感染率和巴氏涂片异常情况。178例连续的艾滋病毒血清阳性女性纳入诗里拉吉医院妇产科。记录所有患者的一般信息和实验室检查结果。按照VCE技术的描述，用棉拭子和艾氏刮匙从子宫颈管、宫颈转化区和阴道获取巴氏涂片。患者被分为两组，齐多夫定组和非齐多夫定组。两组之间的比较采用统计学计算。结果发现，178例艾滋病毒血清阳性女性中有88例（49.4%）接受了齐多夫定治疗。艾滋病毒血清阳性且巴氏涂片异常的女性中，巴氏涂片异常的发生率为59.6%。然而，通过巴氏涂片检测出人类乳头瘤病毒感染的有17例（9.6%）。齐多夫定组和非齐多夫定组之间在统计学上无差异。与未感染人类乳头瘤病毒的艾滋病毒血清阳性女性相比，感染人类乳头瘤病毒的艾滋病毒血清阳性女性宫颈发育异常巴氏涂片异常的可能性显著更高。结论是，携带人类乳头瘤病毒的艾滋病毒血清阳性女性发生宫颈发育异常的风险更高。
