Magnusson M, Magnusson K E, Denneberg T
Department of Nephrology, University of Linköping, Sweden.
Miner Electrolyte Metab. 1992;18(2-5):288-92.
The intestinal permeability in chronic uremic rats on a high- and a low-protein diet was measured with a mixture of differently sized polyethylene glycols (PEG 400 and PEG 1000). The permeability was assessed by the 24-hour urinary recovery of PEG molecules (range 326-1,162 Da) administrated orally or intravenously. The urinary recovery after oral load, when corrected with the recovery after intravenous administration, was significantly enhanced in the uremic rats. A decreased urinary recovery was observed in the groups on the low-protein feed diet. There was also decreased selectivity towards larger PEGs in uremia. The results thus suggest that (i) the intestinal permeability is increased in chronic uremic rats, and (ii) the intestinal permeability is influenced by a low-protein diet.
采用不同大小的聚乙二醇混合物（PEG 400和PEG 1000）测量高蛋白和低蛋白饮食的慢性尿毒症大鼠的肠道通透性。通过口服或静脉注射后24小时尿液中PEG分子（分子量范围326 - 1162 Da）的回收率来评估通透性。口服负荷后经静脉给药回收率校正的尿液回收率在尿毒症大鼠中显著提高。低蛋白饲料组观察到尿液回收率降低。尿毒症时对较大PEG的选择性也降低。因此，结果表明：（i）慢性尿毒症大鼠的肠道通透性增加；（ii）低蛋白饮食会影响肠道通透性。
