Rosato Rosalba, Ciccone Giovannino, Farina Enzo C, Gelormino Elena, Pagano Eva, Senore Carlo, Merletti Franco
Unità di epidemiologia dei tumori, ASO S. Giovanni Battista di Torino, Via Santona 7, 10126 Torino.
Epidemiol Prev. 2003 Jul-Aug;27(4):207-14.
This study was undertaken to evaluate the usefulness of hospital discharge data for monitoring the impact of a regional practice guideline on treatment of colorectal cancer. The aims of the study were: i) estimating process and outcome indicators; ii) exploring the relationship between patient and hospital characteristics and these indicators. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for all risk factors analysed. All 3,614 patients undergoing potentially curative resection for rectal cancer in 75 hospitals in Piedmont (Italy) between 1997 and 2000 were included. Occurrences of abdominoperineal resections (APR), postoperative complications, reinterventions and hospital mortality were 16.2%, 11.0%, 5.5% and 4.4%, respectively. APR was performed more frequently in patients with distant metastases or urgently admitted and by hospitals with a lower volume of cases (< 25 per year) compared to hospital with more than 50 cases per year (OR = 1.50, CI = 1.16-1.94). The strongest predictors for mortality and complications were: older age, distant metastases and urgency of admission. Incidence of complications and of reinterventions was also increased among males and in patients with lesions of the lower rectum. The rate of complications showed an increasing trend during the period, from 8.5% to 14.5% likely reflecting improvement in coding during time. Low hospital workload was associated to a reduced risk of complications and reinterventions, but there was evidence of underreporting of secondary diagnoses and procedures in smaller hospitals. Outcome indicator based on secondary diagnoses and procedures are of limited value in monitoring improvement of care since they reflect also differences in coding during time and among providers.
本研究旨在评估医院出院数据对于监测区域实践指南对结直肠癌治疗影响的有用性。该研究的目的为:i)估计过程和结果指标;ii)探索患者及医院特征与这些指标之间的关系。对所有分析的风险因素调整了比值比(OR)和95%置信区间(CI)。纳入了1997年至2000年期间意大利皮埃蒙特地区75家医院中所有3614例接受直肠癌潜在根治性切除术的患者。腹会阴联合切除术(APR)、术后并发症、再次手术和医院死亡率的发生率分别为16.2%、11.0%、5.5%和4.4%。与每年病例数超过50例的医院相比,远处转移患者或急诊入院患者以及病例数较少(每年<25例)的医院更频繁地进行APR(OR = 1.50,CI = 1.16 - 1.94)。死亡率和并发症的最强预测因素为:年龄较大、远处转移和入院紧急程度。男性以及直肠下段有病变的患者并发症和再次手术的发生率也有所增加。在此期间并发症发生率呈上升趋势,从8.5%升至14.5%,这可能反映了编码随时间的改进。医院工作量低与并发症和再次手术风险降低相关,但有证据表明较小医院存在次要诊断和手术报告不足的情况。基于次要诊断和手术的结果指标在监测护理改善方面价值有限,因为它们还反映了不同时间以及不同医疗机构之间编码的差异。