Rad53：一种确保组蛋白水平精确调节的调控因子。

Rad53: a controller ensuring the fine-tuning of histone levels.

作者信息

Quivy Jean-Pierre, Almouzni Geneviève

机构信息

Institut Curie, Research Section, UMR 218 du CNRS, 75218 Paris cedex 05, France.

出版信息

Cell. 2003 Nov 26;115(5):508-10. doi: 10.1016/s0092-8674(03)00931-0.

DOI:10.1016/s0092-8674(03)00931-0

PMID:14651842

Abstract

Checkpoint proteins are activated in response to genotoxic insults or replication stress to maintain genome integrity. Their function is believed to depend largely on the detection of the DNA damage or defects occurring during replication fork progression.

摘要

检查点蛋白在响应基因毒性损伤或复制应激时被激活，以维持基因组完整性。人们认为它们的功能很大程度上取决于对复制叉进展过程中发生的DNA损伤或缺陷的检测。