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脑和脊髓多发结核瘤:一例报告

Multiple tuberculomas in the brain and spinal cord: a case report.

作者信息

Yen Han-Lin, Lee Reng-Jye, Lin Jui-Wei, Chen Han-Jung

机构信息

Department of Neurosurgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

出版信息

Spine (Phila Pa 1976). 2003 Dec 1;28(23):E499-502. doi: 10.1097/01.BRS.0000099114.40764.46.

Abstract

STUDY DESIGN

A case of disseminated tuberculoma in the spinal cord and brain is reported.

OBJECTIVES

To present a case of disseminated tuberculoma in the spinal cord and brain and to describe the unusual pathologic features and clinical presentation.

SUMMARY AND BACKGROUND

DATA Intramedullary tuberculoma concomitant with intracerebral disseminated tuberculoma is rare. Only one other case has been reported in the world literature. This represents the second reported case of this unusual lesion.

MATERIALS AND METHODS

The authors report a 67-year-old man with miliary tuberculosis of the lung and started on antituberculous therapy. His pulmonary complaints were resolved, but he presented acute paraparesis caused by tuberculomas in the thoracolumbar spinal cord. MRI showed more tuberculomas in the brain stem, cerebellum, and cerebral hemispheres.

RESULTS

After 6 months, the patient's muscle power gradually improved with a combination of medical and surgical management.

CONCLUSIONS

Our experience indicates that antituberculous medication is effective in managing multiple central nervous system tuberculomas. The purpose of surgical intervention is to decompress the cord or brain when progressing neurologic defects occur and to examine the tissue pathologically.

摘要

研究设计

报告一例脊髓和脑内播散性结核瘤病例。

目的

呈现一例脊髓和脑内播散性结核瘤病例,并描述其不寻常的病理特征和临床表现。

总结与背景资料

脊髓内结核瘤合并脑内播散性结核瘤罕见。世界文献中仅报道过一例。本文报道的为此类罕见病变的第二例。

材料与方法

作者报告一名67岁男性,患有粟粒性肺结核并开始接受抗结核治疗。其肺部症状得到缓解,但因胸段和腰段脊髓结核瘤出现急性双下肢轻瘫。磁共振成像显示脑干、小脑和大脑半球有更多结核瘤。

结果

6个月后,通过药物和手术联合治疗,患者肌力逐渐改善。

结论

我们的经验表明,抗结核药物对治疗多发性中枢神经系统结核瘤有效。手术干预的目的是在出现进行性神经功能缺损时对脊髓或脑进行减压,并进行组织病理学检查。

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