Krishnan Shyam Sundar, Patel Bhavinkumar Rameshchandra, Vasudevan Madabushi Chakravarthy
Department of Neurosurgery, Achanta Lakshmipathi Neurosurgical Centre, Voluntary Health Services, Taramani, Chennai, Tamil Nadu, India.
Asian J Neurosurg. 2017 Oct-Dec;12(4):774-778. doi: 10.4103/1793-5482.185073.
Disseminated tuberculomas in the brain and spinal cord are rare. To the best of our knowledge, only nine cases of spinal intra-medullary tuberculomas with cranial involvement have been reported till date. However, involvement of all levels in the spinal cord, brain stem with pan lobar involvement of the cerebrum and cerebellum has not been reported so far. We present such a case of a 12-year-old boy with history of pulmonary tuberculosis, who presented with gradual onset of quadriparesis and generalized seizures. We have discussed the unusual clinical presentation and the temporal changes in magnetic resonance imaging features along with clinical response to treatment. In cases reported so far, the plan of surgical versus medical management has been opted for variably, in cases of spinal intra-medullary involvement with acute neurological deficit. The decision is even more difficult in multilevel spinal intra-medullary tuberculomas. Our patient showed good clinico-radiological improvement with medical management.
脑和脊髓播散性结核瘤较为罕见。据我们所知,迄今为止仅报告了9例合并颅内受累的脊髓髓内结核瘤。然而,脊髓各节段、脑干以及大脑和小脑全叶受累的情况目前尚未见报道。我们报告了这样一例12岁男孩,有肺结核病史,表现为渐进性四肢瘫和全身性癫痫发作。我们讨论了其不寻常的临床表现、磁共振成像特征的时间变化以及对治疗的临床反应。在迄今为止报告的病例中,对于合并急性神经功能缺损的脊髓髓内受累病例,手术与药物治疗方案的选择各不相同。对于多节段脊髓髓内结核瘤,决策更为困难。我们的患者通过药物治疗在临床和影像学上均有良好改善。