Specchia Giorgina, Buquicchio Caterina, Albano Francesco, Liso Arcangelo, Pannunzio Alessandra, Mestice Anna, Rizzi Rita, Pastore Domenico, Liso Vincenzo
Department of Haematology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy.
Leuk Res. 2004 Feb;28(2):115-9. doi: 10.1016/s0145-2126(03)00182-6.
The characteristics of the very rare non-treatment-related chronic myeloid leukemia (nTr-CML) cases have never before been analyzed. The literature up to December 2002 was screened using the Medline database to identify cases of Tr-CML and nTr-CML. We considered five cases with nTr-CML identified among 270 newly diagnosed CML at our Department. Our report thus considers nine cases with nTr-CML compared to 77 affected by Tr-CML as a secondary neoplasm. The median age at the appearance of the first tumor was higher in nTr-CML patients compared to that of the Tr-CML group (P<0.0001). The median age at CML diagnosis was significantly higher in the nTr-CML than in the Tr-CML group (P<0.0001). The proportion of hematological malignancies as first tumor type was not different in the two groups (44% in nTr-CML versus 56% in Tr-CML). Our study underlines that nTr-CML as a second malignancy is a rare entity associated with elderly age.
此前从未对极为罕见的非治疗相关慢性粒细胞白血病（nTr-CML）病例的特征进行过分析。利用Medline数据库筛选了截至2002年12月的文献，以确定治疗相关慢性粒细胞白血病（Tr-CML）和非治疗相关慢性粒细胞白血病（nTr-CML）的病例。我们在本部门新诊断的270例慢性粒细胞白血病中发现了5例nTr-CML。因此，我们的报告中纳入了9例nTr-CML病例，与之相比，有77例受Tr-CML影响的病例为继发性肿瘤。与Tr-CML组相比，nTr-CML患者首次出现肿瘤时的中位年龄更高（P<0.0001）。nTr-CML组慢性粒细胞白血病诊断时的中位年龄显著高于Tr-CML组（P<0.0001）。两组中作为首发肿瘤类型的血液系统恶性肿瘤比例无差异（nTr-CML组为44%，Tr-CML组为56%）。我们的研究强调，nTr-CML作为第二种恶性肿瘤是一种与老年相关的罕见疾病。
