Kim Donghee
Department of Physiology and Biophysics, Finch University of Health Sciences/The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA.
Trends Pharmacol Sci. 2003 Dec;24(12):648-54. doi: 10.1016/j.tips.2003.10.008.
K(+) channels that are activated by free fatty acids (here called K(FA) channels) are found throughout the CNS and in some peripheral tissues. In addition to free fatty acids, membrane stretch (cell swelling), changes in intracellular pH and volatile anaesthetic agents also activate K(FA) channels. Neurotransmitters that bind to G(s)-protein-coupled receptors inhibit K(FA) current via cAMP-mediated phosphorylation. K(FA) channels are native members of the TREK-TRAAK family, which belongs to the tandem-pore class of K(+) (K(2P)) channels. The unique properties of K(FA) channels indicate that they are well suited to sensing various types of stress that occur in the cell.
可被游离脂肪酸激活的钾离子通道（此处称为K(FA)通道）遍布中枢神经系统以及一些外周组织。除游离脂肪酸外，膜拉伸（细胞肿胀）、细胞内pH值变化和挥发性麻醉剂也能激活K(FA)通道。与G(s)蛋白偶联受体结合的神经递质通过cAMP介导的磷酸化作用抑制K(FA)电流。K(FA)通道是TREK - TRAAK家族的天然成员，该家族属于钾离子（K(2P)）通道的双孔类。K(FA)通道的独特特性表明它们非常适合感知细胞中发生的各种应激类型。
