Schiller Peter H, Tehovnik Edward J
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Eur J Neurosci. 2003 Dec;18(11):3127-33. doi: 10.1111/j.1460-9568.2003.03036.x.
The role inhibitory circuits play in target selection with saccadic eye movements was examined in area V1, the frontal eye fields (FEF) and the lateral intraparietal sulcus (LIP) of the Rhesus Macaque monkey by making local infusions of the GABA agonist muscimol and antagonist bicuculline. In V1, both agents greatly interfered with target selection and visual discrimination of stimuli placed into the receptive field of the affected neurons. In the FEF, bicuculline facilitated target selection without affecting visual discrimination and generated many spontaneous saccades. Muscimol in the FEF interfered with saccadic eye-movement generation. In the LIP, bicuculline was ineffective and muscimol had only a small effect. These findings suggest that in the FEF GABAergic inhibitory circuits play a central role in eye-movement generation whereas in V1 these circuits are essential for visual analysis. Inhibitory circuits in the LIP do not appear to play a central role in target selection and in visual discrimination.
通过局部注入γ-氨基丁酸（GABA）激动剂蝇蕈醇和拮抗剂荷包牡丹碱，研究了抑制性回路在恒河猴V1区、额叶眼区（FEF）和顶叶内沟（LIP）的扫视眼动目标选择中的作用。在V1区，这两种药物都极大地干扰了目标选择以及对置于受影响神经元感受野内刺激的视觉辨别。在额叶眼区，荷包牡丹碱促进了目标选择，而不影响视觉辨别，并引发了许多自发扫视。额叶眼区的蝇蕈醇干扰了扫视眼动的产生。在顶叶内沟，荷包牡丹碱无效，蝇蕈醇只有很小的作用。这些发现表明，在额叶眼区，GABA能抑制性回路在眼动产生中起核心作用，而在V1区，这些回路对视觉分析至关重要。顶叶内沟的抑制性回路似乎在目标选择和视觉辨别中不发挥核心作用。
