White Morris F
Howard Hughes Medical Institute, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA.
Science. 2003 Dec 5;302(5651):1710-1. doi: 10.1126/science.1092952.
The signaling pathways used by insulin have been identified [M. White, Insulin Signaling Pathway, Sci. STKE (Connections Map, as seen November 2003), http://stke.sciencemag.org/cgi/cm/cmp_12069]. Now our challenge is to understand how the failure of these signals is associated with obesity and the progressive failure of pancreatic beta cells that leads to diabetes. Whether better management of chronic inflammation can improve insulin action is an important area of investigation. Drugs that stimulate IRS2 (insulin receptor substrate protein 2) synthesis or signaling might be a good starting point. This knowledge will lead to rational strategies that prevent or cure diabetes.
胰岛素所使用的信号通路已被确定[M. 怀特，《胰岛素信号通路》，《科学信号》（连接图谱，2003年11月所见），http://stke.sciencemag.org/cgi/cm/cmp_12069]。现在我们面临的挑战是弄清楚这些信号的失灵如何与肥胖以及导致糖尿病的胰腺β细胞的渐进性失灵相关联。更好地管理慢性炎症是否能改善胰岛素作用是一个重要的研究领域。刺激IRS2（胰岛素受体底物蛋白2）合成或信号传导的药物可能是一个很好的切入点。这些知识将带来预防或治愈糖尿病的合理策略。
