冠状动脉疾病与MEF2A转录因子

Coronary artery disease and the MEF2A transcription factor.

作者信息

Olson Eric N

机构信息

Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

Sci Aging Knowledge Environ. 2003 Dec 3;2003(48):pe33. doi: 10.1126/sageke.2003.48.pe33.

DOI:10.1126/sageke.2003.48.pe33

PMID:14657507

Abstract

Coronary artery disease (CAD) that results from lesions of the vascular wall is a major cause of myocardial infarction (MI) and stroke. A human pedigree with a predisposition to CAD and MI has been shown to harbor a mutation in the MEF2A transcription factor. These findings reveal a new function for this regulator of cardiovascular development and raise intriguing questions about the underlying mechanisms of CAD.

摘要

由血管壁病变导致的冠状动脉疾病（CAD）是心肌梗死（MI）和中风的主要原因。一个对CAD和MI具有遗传易感性的人类家系已被证明在MEF2A转录因子中存在突变。这些发现揭示了这种心血管发育调节因子的新功能，并引发了关于CAD潜在机制的有趣问题。