日本患者中肿瘤坏死因子α基因-308和-238位点启动子多态性与寻常型银屑病之间无关联。
Lack of association between the promoter polymorphisms at positions -308 and -238 of the tumor necrosis factor alpha gene and psoriasis vulgaris in Japanese patients.
作者信息
Tsunemi Yuichiro, Nishibu Akiko, Saeki Hidehisa, Oyama Noritaka, Nakamura Koichiro, Kishimoto Megumi, Mitsui Hiroshi, Tada Yayoi, Torii Hideshi, Komine Mayumi, Asahina Akihiko, Kaneko Fumio, Tamaki Kunihiko
机构信息
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.
出版信息
Dermatology. 2003;207(4):371-4. doi: 10.1159/000074117.
BACKGROUND
Psoriasis features an increased level and activity of tumor necrosis factor alpha (TNF-alpha). The TNF-alpha gene has single nucleotide polymorphisms (SNPs) at positions -308 (-308G>A) and -238 (-238G>A) in the promoter region, and the -238G>A SNP has been reported to be associated with psoriasis vulgaris (PV) and psoriatic arthritis in Caucasians.
OBJECTIVE
To examine whether these SNPs are associated with susceptibility to PV in Japanese patients, we investigated the genotype and allele frequencies at each SNP in Japanese PV patients and in controls.
METHODS
We examined 163 PV patients and 96 healthy individuals. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method.
RESULTS
No significant association between the genotypes or alleles of these SNPs and susceptibility to PV was observed.
CONCLUSION
These SNPs themselves are not associated with susceptibility to PV in the Japanese.
背景
银屑病的特征是肿瘤坏死因子α（TNF-α）水平升高及活性增强。TNF-α基因在启动子区域的-308（-308G>A）和-238（-238G>A）位点存在单核苷酸多态性（SNP），并且据报道-238G>A SNP与白种人中的寻常型银屑病（PV）和银屑病关节炎相关。
目的
为了研究这些SNP是否与日本患者患PV的易感性相关，我们调查了日本PV患者和对照组中每个SNP的基因型和等位基因频率。
方法
我们检测了163例PV患者和96名健康个体。使用聚合酶链反应-限制性片段长度多态性方法进行基因分型。
结果
未观察到这些SNP的基因型或等位基因与PV易感性之间存在显著关联。
结论
这些SNP本身与日本人患PV的易感性无关。
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