Zhuang Le, Ma Weiyuan, Cai Daxing, Zhong Hua, Sun Qing
Department of Dermatology, Qilu Hospital, Shandong University, Jinan, China.
PLoS One. 2013 Dec 4;8(12):e68827. doi: 10.1371/journal.pone.0068827. eCollection 2013.
Tumor necrosis factor-α (TNF-α) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-α polymorphisms and psoriasis risk.
We performed a meta-analysis to evaluate the associations between TNF-α polymorphisms and psoriasis. Electronic searches of Pubmed, Embase, and Web of Science were performed for all publications on the associations between TNF-α polymorphisms and psoriasis through September 26, 2012. The pooled odds ratios (ORs) with their 95% confidence interval (95%CIs) were calculated to assess the associations.
Sixteen case-control studies with a total of 2,253 psoriasis cases and 1,947 controls on TNF-α 308 G/A polymorphism and fourteen studies on TNF-α 238 G/A polymorphism with 2,104 cases and 1,838 controls were finally included into the meta-analysis. Overall, TNF-α 308 G/A polymorphism was significantly associated with decreased risk of psoriasis under three genetic comparison models (for A versus G: fixed-effects OR 0.71, 95%CI 0.62-0.82, P < 0.001; for AG versus GG: fixed-effects OR 0.67, 95%CI 0.57-0.78, P < 0.001; for AA/AG versus GG: fixed-effects OR 0.67, 95%CI 0.58-0.78, P < 0.001). In addition, TNF-α 238 G/A polymorphism was associated with increased risk of psoriasis under three genetic models (for A versus G: fixed-effects OR 2.46, 95%CI 2.04-2.96, P < 0.001; for AG versus GG: fixed-effects OR 2.69, 95%CI 2.20-3.28, P < 0.001; for AA/AG versus GG: fixed-effects OR 2.68, 95%CI 2.20-3.26, P < 0.001). Subgroup analysis by ethnicity identified a significant association between TNF-α 308 G/A polymorphism and decreased risk of psoriasis in both Caucasians and Asians and a significant association between TNF-α 238 G/A polymorphism and increased risk of psoriasis in Caucasians.
The meta-analysis suggests that TNF-α 308 G/A polymorphism is associated with decreased risk of psoriasis, while TNF-α 238 G/A is associated with increased risk of psoriasis.
肿瘤坏死因子-α（TNF-α）可能在银屑病顽固的炎症和过度增殖性皮肤病中起重要作用，且TNF-α基因多态性与银屑病风险之间可能存在关联。
我们进行了一项荟萃分析，以评估TNF-α基因多态性与银屑病之间的关联。通过对PubMed、Embase和Web of Science进行电子检索，查找截至2012年9月26日所有关于TNF-α基因多态性与银屑病关联的出版物。计算合并比值比（OR）及其95%置信区间（95%CI）以评估关联。
最终纳入荟萃分析的有16项病例对照研究，共2253例银屑病病例和1947例对照，涉及TNF-α 308 G/A多态性；还有14项研究，共2104例病例和1838例对照，涉及TNF-α 238 G/A多态性。总体而言，在三种遗传比较模型下，TNF-α 308 G/A多态性与银屑病风险降低显著相关（A与G比较：固定效应OR 0.71，95%CI 0.62 - 0.82，P < 0.001；AG与GG比较：固定效应OR 0.67，95%CI 0.57 - 0.78，P < 0.001；AA/AG与GG比较：固定效应OR 0.67，95%CI 0.58 - 0.78，P < 0.001）。此外，在三种遗传模型下，TNF-α 238 G/A多态性与银屑病风险增加相关（A与G比较：固定效应OR 2.46，95%CI 2.04 - 2.96，P < 0.001；AG与GG比较：固定效应OR 2.69，95%CI 2.20 - 3.28，P < 0.001；AA/AG与GG比较：固定效应OR 2.68，95%CI 2.20 - 3.26，P < 0.001）。按种族进行的亚组分析表明，TNF-α 308 G/A多态性与白种人和亚洲人银屑病风险降低均显著相关，TNF-α 238 G/A多态性与白种人银屑病风险增加显著相关。
荟萃分析表明，TNF-α 308 G/A多态性与银屑病风险降低相关，而TNF-α 238 G/A多态性与银屑病风险增加相关。
