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[基因工程在严重缺血治疗中的潜力与前景]

[Genetic engineering potential and perspectives in the management of critical ischemia].

作者信息

Konstantinov B A, Bochkov N P, Gavrilenko A V, Voronov D A, Tarantul V Z, Sheremet'eva G F, Skrylev S I, Khaĭdarova N V

机构信息

Department of Vascular Surgery, Russian Research Center of Surgery, Russian Academy of Medical Sciences, Moscow, Russia.

出版信息

Angiol Sosud Khir. 2003;9(3):14-8.

Abstract

The paper presents a new approach to management of lower limb critical ischemia which implements recent advances in molecular biology and genetic engineering technologies. A new original compound incorporating angiogenin gene was developed to activate neoangiogenesis processes after injection into living tissues. Experimental data evidence a potential efficacy of new method for complex management of critical ischemia.

摘要

本文提出了一种下肢严重缺血的新管理方法,该方法应用了分子生物学和基因工程技术的最新进展。开发了一种新的含有血管生成素基因的原创化合物,在注入活体组织后可激活新生血管生成过程。实验数据证明了这种新方法对严重缺血进行综合管理的潜在疗效。

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