Bobek Vladimir, Taltynov Oliver, Pinterova Daniela, Kolostova Katarina
Third Faculty of Medicine, Charles University Prague, Department of Tumor Biology, Czech Republic.
Vascul Pharmacol. 2006 Jun;44(6):395-405. doi: 10.1016/j.vph.2006.03.009. Epub 2006 May 15.
The limitations of surgical revascularisation and pharmacological treatment in peripheral arterial occlusive disease (PAOD) are well recognized. Therapeutic options for critical leg ischemia are consequently limited to percutaneous transluminal angioplasty (PTA) or surgical revascularisation. Unfortunately, many patients with critical leg ischemia are poor candidates for either procedure. Therapeutic angiogenesis is a novel promising tool to treat these patients. Experimental and clinical and trials of gene transfer for therapeutic angiogenesis have already shown some clinical efficacy. This review is focused on gene transfer techniques in preclinical and clinical therapeutic angiogenesis, angiogenic growth factors, vectors, delivery methods and routes. The results of clinical and experimental studies, safety and side effects of gene therapy, and the perspectives of future research are also discussed.
外科血管重建术和药物治疗在周围动脉闭塞性疾病（PAOD）中的局限性已得到广泛认可。因此，严重下肢缺血的治疗选择仅限于经皮腔内血管成形术（PTA）或外科血管重建术。不幸的是，许多严重下肢缺血患者都不适合这两种手术。治疗性血管生成是治疗这些患者的一种新的有前景的工具。用于治疗性血管生成的基因转移的实验、临床和试验已经显示出一定的临床疗效。本综述聚焦于临床前和临床治疗性血管生成中的基因转移技术、血管生成生长因子、载体、递送方法和途径。还讨论了临床和实验研究的结果、基因治疗的安全性和副作用以及未来研究的前景。
