Reed E, Cohen D J, Barr M L, Ho E, Reemtsma K, Rose E A, Hardy M, Suciu-Foca N
Department of Pathology, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
Transplant Proc. 1992 Dec;24(6):2670-1.
Study of long-term survival of heart allografts shows that AA males and females have lower graft survival rates than those observed in NAC recipients. Primary kidney allografts in AA males, but not females, also display lower 5-year survival rates compared to those observed in the corresponding populations of NAC. Comparison of graft survival in the overall population of male and female recipients of kidney allografts shows that females have higher graft survival rates, probably as a result of better HLA matching. The level of alloantibody activity in posttransplantation sera is similar in the two populations, suggesting that factors other than HLA mismatching may contribute to the higher degree of graft failure in AA recipients.
心脏同种异体移植长期存活的研究表明，非裔美国男性和女性的移植物存活率低于非裔美国人对照组（NAC）受者。非裔美国男性而非女性的原发性肾脏同种异体移植与相应的非裔美国人对照组相比，5年存活率也较低。对肾脏同种异体移植男性和女性受者总体人群的移植物存活情况进行比较表明，女性的移植物存活率更高，这可能是由于更好的HLA匹配。两个群体移植后血清中的同种抗体活性水平相似，这表明除了HLA不匹配之外的因素可能导致非裔美国受者更高程度的移植物失败。
