Richter Diethelm W, Manzke Till, Wilken Bernd, Ponimaskin Evgeni
II. Physiological Institute, Neuro- and Sensory Neurophysiology, University of Göttingen, Humboldtallee 23, D37073 Göttingen, Germany.
Trends Mol Med. 2003 Dec;9(12):542-8. doi: 10.1016/j.molmed.2003.10.010.
Disturbances of breathing arising from failures of the respiratory center are not uncommon. Among them, breath holding and apnea occur most frequently as consequences of pulmonary and cardiac diseases, hypoxia, head trauma, cerebral inflammatory processes, genetic defects, degenerative brain diseases, alcoholism, deep anesthesia and drug overdose. They are often life-threatening and fail to respond to existing pharmacotherapies. After extensive research, there is now a reliable basis for new strategies to treat respiratory disturbances by pharmacological manipulation of intracellular signaling pathways, particularly those involving the serotonin receptor family. Specific activation of these pathways effectively prevails respiratory disturbances and can be extended to treatment of life-threatening respiratory disorders in patients.
由呼吸中枢功能衰竭引起的呼吸障碍并不罕见。其中，屏气和呼吸暂停最为常见，是肺部和心脏疾病、缺氧、头部外伤、脑部炎症、基因缺陷、退行性脑疾病、酗酒、深度麻醉和药物过量的后果。它们常常危及生命，且对现有的药物治疗无效。经过广泛研究，现在有了可靠的依据来制定新策略，通过对细胞内信号通路进行药理学调控来治疗呼吸障碍，尤其是涉及血清素受体家族的信号通路。这些信号通路的特异性激活能有效克服呼吸障碍，并可推广至治疗患者危及生命的呼吸紊乱。
