血清素在呼吸功能和障碍中的作用。
The role of serotonin in respiratory function and dysfunction.
机构信息
Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (CRN2 M), Unité Mixte de Recherche 6231, CNRS-Université Aix-Marseille II & III, Faculté Saint Jérôme, Marseille, France.
出版信息
Respir Physiol Neurobiol. 2010 Nov 30;174(1-2):76-88. doi: 10.1016/j.resp.2010.08.017. Epub 2010 Aug 27.
Abstract
Serotonin (5-HT) is a neuromodulator-transmitter influencing global brain function. Past and present findings illustrate a prominent role for 5-HT in the modulation of ponto-medullary autonomic circuits. 5-HT is also involved in the control of neurotrophic processes during pre- and postnatal development of neural circuits. The functional implications of 5-HT are particularly illustrated in the alterations to the serotonergic system, as seen in a wide range of neurological disorders. This article reviews the role of 5-HT in the development and control of respiratory networks in the ponto-medullary brainstem. The review further examines the role of 5-HT in breathing disorders occurring at different stages of life, in particular, the neonatal neurodevelopmental diseases such as Rett, sudden infant death and Prader-Willi syndromes, adult diseases such as sleep apnoea and mental illness linked to neurodegeneration.
摘要
血清素（5-HT）是一种影响大脑整体功能的神经递质。过去和现在的研究结果表明，5-HT 在调节桥延髓自主神经回路方面起着重要作用。5-HT 还参与了神经回路在产前和产后发育过程中的神经营养过程的控制。5-HT 的功能意义在广泛的神经障碍中，特别是在血清素能系统的改变中得到了特别说明。本文综述了 5-HT 在桥延髓脑干呼吸网络的发育和控制中的作用。该综述进一步研究了 5-HT 在生命不同阶段发生的呼吸障碍中的作用，特别是神经发育性疾病，如雷特综合征、婴儿猝死和普拉德-威利综合征，以及成人疾病，如睡眠呼吸暂停和与神经退行性变相关的精神疾病。
相似文献
1
The role of serotonin in respiratory function and dysfunction.血清素在呼吸功能和障碍中的作用。
Respir Physiol Neurobiol. 2010 Nov 30;174(1-2):76-88. doi: 10.1016/j.resp.2010.08.017. Epub 2010 Aug 27.
2
Subtle autonomic and respiratory dysfunction in sudden infant death syndrome associated with serotonergic brainstem abnormalities: a case report.与血清素能脑干异常相关的婴儿猝死综合征中的细微自主神经和呼吸功能障碍：一例报告
J Neuropathol Exp Neurol. 2005 Aug;64(8):689-94. doi: 10.1097/01.jnen.0000174334.27708.43.
3
Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome.Necdin在小鼠呼吸网络的5-羟色胺能调节中发挥作用：对普拉德-威利综合征的启示。
J Neurosci. 2008 Feb 13;28(7):1745-55. doi: 10.1523/JNEUROSCI.4334-07.2008.
4
Abnormalities of serotonergic neurotransmission in animal models of SUDEP.癫痫性猝死动物模型中血清素能神经传递的异常。
Epilepsy Behav. 2017 Jun;71(Pt B):174-180. doi: 10.1016/j.yebeh.2015.06.008. Epub 2015 Aug 10.
5
Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons.脑干5-羟色胺能神经元较少的新生大鼠中与呼吸紊乱相关的严重自发性心动过缓。
Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1783-96. doi: 10.1152/ajpregu.00122.2009. Epub 2009 Apr 15.
6
The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis.人类延髓发育中的 5-羟色胺能解剖结构：对儿童自主神经功能障碍的启示。
J Chem Neuroanat. 2011 Jul;41(4):182-99. doi: 10.1016/j.jchemneu.2011.05.004. Epub 2011 May 27.
7
Alterations in respiratory behavior, brain neurochemistry and receptor density induced by pharmacologic suppression of sleep in the neonatal period.新生儿期药物性睡眠抑制引起的呼吸行为、脑神经化学及受体密度的改变。
Brain Res Dev Brain Res. 2000 Apr 14;120(2):181-9. doi: 10.1016/s0165-3806(00)00008-0.
8
Medullary serotonin defects and respiratory dysfunction in sudden infant death syndrome.婴儿猝死综合征中的延髓血清素缺陷与呼吸功能障碍
Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):133-43. doi: 10.1016/j.resp.2009.05.010. Epub 2009 May 27.
9
Eliminating medullary 5-HT neurons delays arousal and decreases the respiratory response to repeated episodes of hypoxia in neonatal rat pups.消除延髓5-羟色胺能神经元会延迟新生大鼠幼崽的觉醒，并降低其对反复缺氧发作的呼吸反应。
J Appl Physiol (1985). 2016 Mar 1;120(5):514-25. doi: 10.1152/japplphysiol.00560.2014. Epub 2015 Dec 23.
10
Serotonin (5-HT) and migraine.血清素（5-羟色胺）与偏头痛。
Headache. 1994 Jul-Aug;34(7):408-17. doi: 10.1111/j.1526-4610.1994.hed3407408.x.
引用本文的文献
1
Increased Fos immunoreactivity in astrocytes in the raphe pallidus under hypoxia, not hypercapnia.在缺氧而非高碳酸血症条件下，中缝苍白核星形胶质细胞中Fos免疫反应性增加。
Histochem Cell Biol. 2025 Sep 17;163(1):91. doi: 10.1007/s00418-025-02420-2.
2
Serotonergic receptor binding in the brainstem in the Sudden Infant Death Syndrome in a high-risk population.高危人群中婴儿猝死综合征患者脑干中的5-羟色胺能受体结合情况
PLoS One. 2025 Sep 10;20(9):e0330940. doi: 10.1371/journal.pone.0330940. eCollection 2025.
3
Activation of serotonergic system with fluoxetine or 5-HTP restores blunted hypercapnic ventilatory response in Parkinson's disease model.用氟西汀或5-羟色氨酸激活血清素能系统可恢复帕金森病模型中减弱的高碳酸血症通气反应。
Sci Rep. 2025 Jul 16;15(1):25712. doi: 10.1038/s41598-025-10994-z.
4
Fischer's ratio and DNA damage in hypoxemia-induced brain injury in rat model: prophylactic role of quercetin and mexamine supplementation.大鼠模型中低氧血症诱导脑损伤时的费舍尔比率与DNA损伤：槲皮素和美金刚胺补充剂的预防作用
PLoS One. 2025 Mar 18;20(3):e0319898. doi: 10.1371/journal.pone.0319898. eCollection 2025.
5
The Influence of Serotonergic Signaling on Quality of Life, Depression, Insomnia, and Hypoxia in Obstructive Sleep Apnea Patients: Cross-Sectional Study.血清素能信号传导对阻塞性睡眠呼吸暂停患者生活质量、抑郁、失眠和缺氧的影响：横断面研究
J Clin Med. 2025 Jan 12;14(2):445. doi: 10.3390/jcm14020445.
6
Drug repurposing in Rett and Rett-like syndromes: a promising yet underrated opportunity?雷特综合征及类雷特综合征中的药物重新利用：一个有前景但被低估的机会？
Front Med (Lausanne). 2024 Jul 29;11:1425038. doi: 10.3389/fmed.2024.1425038. eCollection 2024.
7
The hypoxic respiratory response of the pre-Bötzinger complex.前包钦格复合体的低氧呼吸反应。
Heliyon. 2024 Jul 11;10(14):e34491. doi: 10.1016/j.heliyon.2024.e34491. eCollection 2024 Jul 30.
8
Fischer's oligopeptide ratio in ischemic hypoxia: prophylactic amendment of sophoretin and melatonin supplementation.缺血缺氧时的费舍尔寡肽比率：槐角素与褪黑素补充剂的预防性修正
Future Sci OA. 2024 May 20;10(1):FSO911. doi: 10.2144/fsoa-2023-0117. eCollection 2024.
9
Vocal and tongue exercise in early to mid-stage Parkinson disease using the Pink1-/- rat.使用 Pink1-/- 大鼠进行帕金森病早中期的嗓音和舌部锻炼。
Brain Res. 2024 Aug 15;1837:148958. doi: 10.1016/j.brainres.2024.148958. Epub 2024 Apr 27.
10
Impact of Serotonergic 5HT and 5HT Receptor Activation on the Respiratory Response to Hypercapnia in a Rat Model of Parkinson's Disease.血清素能5HT和5HT受体激活对帕金森病大鼠模型中高碳酸血症呼吸反应的影响
Int J Mol Sci. 2024 Apr 17;25(8):4403. doi: 10.3390/ijms25084403.
本文引用的文献
1
Physiological definition of upper airway obstructions in mouse model for Rett syndrome.瑞特综合征小鼠模型中上呼吸道阻塞的生理学定义。
Respir Physiol Neurobiol. 2010 Sep 30;173(2):146-56. doi: 10.1016/j.resp.2010.07.006. Epub 2010 Jul 24.
2
Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals.5-羟色胺1A和5-羟色胺2A阳性细胞在年龄匹配的对照个体和阿尔茨海默病患者脑干中的定位。
Age (Dordr). 2010 Dec;32(4):483-95. doi: 10.1007/s11357-010-9152-x. Epub 2010 May 28.
3
Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data.神经退行性疾病的精神药理学神经保护：评估临床前数据。
J Neuropsychiatry Clin Neurosci. 2010 Winter;22(1):8-18. doi: 10.1176/jnp.2010.22.1.8.
4
The role of medullary serotonin (5-HT) neurons in respiratory control: contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation.延髓5-羟色胺（5-HT）神经元在呼吸控制中的作用：对平静呼吸、二氧化碳化学感受和体温调节的贡献。
J Appl Physiol (1985). 2010 May;108(5):1425-32. doi: 10.1152/japplphysiol.01270.2009. Epub 2010 Feb 4.
5
Upper airway dysfunction of Tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei.Tau-P301L 小鼠的上呼吸道功能障碍与中脑和桥延脑核的 tau 病相关。
J Neurosci. 2010 Feb 3;30(5):1810-21. doi: 10.1523/JNEUROSCI.5261-09.2010.
6
Postnatal changes in tryptophan hydroxylase and serotonin transporter immunoreactivity in multiple brainstem nuclei of the rat: implications for a sensitive period.大鼠脑干多个核团中色氨酸羟化酶和 5-羟色胺转运体免疫反应性的产后变化：对敏感期的影响。
J Comp Neurol. 2010 Apr 1;518(7):1082-97. doi: 10.1002/cne.22265.
7
Brainstem serotonergic deficiency in sudden infant death syndrome.婴儿猝死综合征中的脑干 5-羟色胺能缺乏。
JAMA. 2010 Feb 3;303(5):430-7. doi: 10.1001/jama.2010.45.
8
Current treatment and recent clinical research in Alzheimer's disease.阿尔茨海默病的当前治疗方法与近期临床研究
Mt Sinai J Med. 2010 Jan-Feb;77(1):3-16. doi: 10.1002/msj.20165.
9
Early abnormalities of post-sigh breathing in a mouse model of Rett syndrome.雷特综合征小鼠模型中叹息后呼吸的早期异常。
Respir Physiol Neurobiol. 2010 Feb 28;170(2):173-82. doi: 10.1016/j.resp.2009.12.009. Epub 2009 Dec 28.
Zotero 插件