Senn H J, Peyer P
Dtsch Med Wochenschr. 1978 Jan 20;103(3):101-7. doi: 10.1055/s-0028-1104389.
In 36 patients with neoplastic diseases 72 episodes of hypercalcaemia with serum-calcium levels greater than or equal to 2.75 mmol/l were treated (19 breast carcinoma; 9 bronchial or lung carcinoma; 5 multiple myeloma; 1 each jejunal carcinoid, malignant lymphoma, phaeochromocytoma). Cardinal symptoms were mental, neuromuscular and renal during the hypercalcaemic episodes. Mithramycin is preferred to other methods (infusion of sodium chloride and frusemide, prednisone, sodium-potassium-phosphate infusion) of treating acute or subacute hypercalcaemia. Mithramycin in a single injection of 20-25 microgram/kg body-weight intravenously is usually sufficient to counteract a hypercalcaemic phase for at least 7-10 days, often much longer. There was a highly significant fall in serum-calcium levels from two days onwards after mithramycin injection. Toxic side-effects were minimal and restricted to transitory increase in transaminase levels, initially 5-6 times normal with a maximum on the third day and normalisation on the fifth day after mithramycin administration.
对36例肿瘤疾病患者的72次血清钙水平大于或等于2.75 mmol/l的高钙血症发作进行了治疗（19例乳腺癌；9例支气管癌或肺癌；5例多发性骨髓瘤；空肠类癌、恶性淋巴瘤、嗜铬细胞瘤各1例）。高钙血症发作期间的主要症状为精神、神经肌肉和肾脏方面的症状。与其他治疗急性或亚急性高钙血症的方法（输注氯化钠和速尿、泼尼松、输注磷酸钠钾）相比，更倾向于使用光辉霉素。静脉注射20 - 25微克/千克体重的单次剂量光辉霉素通常足以对抗高钙血症阶段至少7 - 10天，通常时间更长。注射光辉霉素后两天起血清钙水平显著下降。毒性副作用极小，仅限于转氨酶水平短暂升高，最初是正常水平的5 - 6倍，在给药后第三天达到最高，第五天恢复正常。
