Kutcher Stan, Aman Michael, Brooks Sarah J, Buitelaar Jan, van Daalen Emma, Fegert Jörg, Findling Robert L, Fisman Sandra, Greenhill Laurence L, Huss Michael, Kusumakar Vivek, Pine Daniel, Taylor Eric, Tyano Sam
Dalhousie University Department of Psychiatry, QE II Health Sciences Centre, Abbie J. Lane Building-Suite 9212, 5909 Veterans' Memorial Lane, Halifax, Nova Scotia, B3H 2E2, Canada.
Eur Neuropsychopharmacol. 2004 Jan;14(1):11-28. doi: 10.1016/s0924-977x(03)00045-2.
Researchers and clinicians worldwide share concerns that many youngsters with attention-deficit/hyperactivity disorder (ADHD) and/or disruptive behaviour disorders (DBDs) do not receive appropriate treatment despite availability of effective therapies. At the request of Johnson and Johnson (sponsor), 11 international experts in child and adolescent psychiatry were selected by Professor Stan Kutcher (chair) to address these concerns. This paper describes the experts' consensus conclusions, including treatment practice suggestions for physicians involved in the early treatment of youngsters with ADHD (or hyperkinetic disorder, in countries preferring this classification) and/or DBDs internationally: suggested first-line treatment for ADHD without comorbidity is psychostimulant medication aided by psychosocial intervention. For ADHD with comorbid conduct disorder (CD), psychosocial intervention combined with pharmacotherapy is suggested. For primary CD, suggested first-line treatment is psychosocial intervention, with pharmacotherapy considered as an 'add-on' when aggression/impulsivity is marked and persistent. Pharmacotherapy requires careful titration; full-day coverage is the suggested goal. Regular long-term follow-up is recommended.
全球的研究人员和临床医生都担心,尽管有有效的治疗方法,但许多患有注意力缺陷多动障碍(ADHD)和/或破坏性行为障碍(DBD)的青少年并未得到适当治疗。应强生公司(赞助商)的要求,斯坦·库彻教授(主席)挑选了11位国际儿童和青少年精神病学专家来解决这些问题。本文介绍了专家们的共识结论,包括为参与国际上对患有ADHD(或在倾向于这种分类的国家中为多动障碍)和/或DBD的青少年进行早期治疗的医生提供的治疗实践建议:对于无共病的ADHD,建议的一线治疗是心理社会干预辅助下的精神兴奋剂药物治疗。对于合并品行障碍(CD)的ADHD,建议心理社会干预与药物治疗相结合。对于原发性CD,建议的一线治疗是心理社会干预,当攻击/冲动行为明显且持续时,药物治疗可作为“附加治疗”考虑。药物治疗需要仔细滴定;建议的目标是全天覆盖。建议定期进行长期随访。