Welge-Luessen Antje, Hauser Rolf, Schmid Nevenka, Kappos Ludwig, Probst Rudolf
Department of Otorhinolaryngology, University of Basel, Kantonsspital, Petersgraben 4, CH-4031 Basel, Switzerland.
Laryngoscope. 2003 Dec;113(12):2151-6. doi: 10.1097/00005537-200312000-00019.
Some migraine and cluster headaches may be triggered by stimulation of intranasal contact points via the trigeminovascular system. Endonasal surgery is successful in some patients, but long-term outcomes have not been reported.
Prospective.
This investigation included 20 patients with a mean 18-year history of refractory cluster or migraine headaches who were selected for surgery. All had endoscopically visible endonasal contact as well as a positive preoperative cocaine test result. Changes in pain severity and frequency and duration of headache attacks were statistically rated using a MANOVA. Follow-up averaged 112 months.
Almost 10 years after surgery, six patients remained completely free of pain, seven had significant symptom improvement, and seven received no benefit from surgery (65% improvement). Two patients had been free of all symptoms for 7 and 8 years, respectively, before complaints returned.
Our data suggest that some patients with refractory headaches and endonasal contact areas benefit from surgery, thereby supporting the existence of a connection between the two. Even though it is clear that surgery should be considered only if all other treatments have failed, a success rate of 65% over almost 10 years justifies evaluation of this option. Preoperative patient selection remains crucial and warrants further investigation.
一些偏头痛和丛集性头痛可能通过三叉神经血管系统刺激鼻内接触点而引发。鼻内手术在一些患者中取得成功,但长期疗效尚未见报道。
前瞻性研究。
本研究纳入20例难治性丛集性或偏头痛患者,平均病史18年,均入选手术治疗。所有患者在内窥镜下均可见鼻内接触点,且术前可卡因试验结果为阳性。使用多变量方差分析对疼痛严重程度、头痛发作频率和持续时间的变化进行统计学评分。随访平均112个月。
术后近10年,6例患者完全无痛,7例症状明显改善,7例未从手术中获益(改善率65%)。2例患者在症状复发前分别有7年和8年无症状。
我们的数据表明,一些难治性头痛且有鼻内接触区域的患者可从手术中获益,从而支持两者之间存在关联。尽管很明显只有在所有其他治疗均失败时才应考虑手术,但近10年65%的成功率证明对该手术方案进行评估是合理的。术前患者选择仍然至关重要,值得进一步研究。