Lavalle Salvatore, Pace Annalisa, Magliulo Giuseppe, Lentini Mario, Lechien Jerome Rene, Calvo-Henriquez Christian, Parisi Federica Maria, Iannella Giannicola, Maniaci Antonino, Messineo Daniela
Department of Medicine and Surgery, University of Enna "Kore", 94100 Enna, Italy.
Department of 'Organi di Senso', University "Sapienza", Viale Dell'università, 33, 00185 Rome, Italy.
Diagnostics (Basel). 2025 Jan 7;15(2):121. doi: 10.3390/diagnostics15020121.
Rhinogenic contact point headache (RCPH) is a controversial secondary headache disorder involving mucosal contact points in the nasal sinuses. The efficacy of surgical versus medical management has been debated, with some studies showing excellent long-term outcomes but others citing placebo effects. This study aimed to clarify the correlation with nasal anatomical variation detected by CT and RCPH treatment outcomes. A prospective cohort study was conducted on 90 RCPH patients undergoing surgery or medical therapy. Patients were diagnosed using CT scans, endoscopy, and lidocaine testing. The surgery group had endoscopic procedures to remove contact points. The medical group received intranasal steroids. Outcomes were measured by visual analog scale (VAS) for pain and headache frequency. Predictors like age, gender, and nasal anatomical variations were analyzed. The surgery group showed significant reductions in VAS scores (6.02 to 2.51, < 0.001) and headache frequency (9.11 to 3.04, < 0.001). The medical group did not improve significantly. All nasal subtypes improved with surgery but concha bullosa had worse VAS outcomes (4.0) than septal deviation (1.8, < 0.001) or spur (1.73, < 0.001). Multivariate analysis found nasal anomalies predicted postoperative VAS scores ( < 0.001) but not headache frequency ( = 0.255). Surgery demonstrated superiority over medications for RCPH. This study provides new evidence that preoperative CT scans should be considered a non-invasive gold standard for analyzing nasal subtypes as they significantly influence surgical success, with concha bullosa associated with worse pain relief. Larger studies should validate these findings to optimize RCPH management.
鼻源性接触点性头痛(RCPH)是一种存在争议的继发性头痛疾病,涉及鼻窦中的黏膜接触点。手术治疗与药物治疗的疗效一直存在争议,一些研究显示长期效果良好,但另一些研究则提及安慰剂效应。本研究旨在阐明CT检测到的鼻腔解剖变异与RCPH治疗结果之间的相关性。对90例接受手术或药物治疗的RCPH患者进行了一项前瞻性队列研究。通过CT扫描、内镜检查和利多卡因测试对患者进行诊断。手术组采用内镜手术去除接触点。药物组接受鼻内类固醇治疗。通过视觉模拟评分法(VAS)测量疼痛和头痛频率来评估治疗结果。分析了年龄、性别和鼻腔解剖变异等预测因素。手术组的VAS评分(从6.02降至2.51,<0.001)和头痛频率(从9.11降至3.04,<0.001)显著降低。药物组没有显著改善。所有鼻腔亚型经手术治疗后均有改善,但泡状鼻甲的VAS结果(4.0)比鼻中隔偏曲(1.8,<0.001)或鼻棘(1.73,<0.001)更差。多变量分析发现鼻腔异常可预测术后VAS评分(<0.001),但不能预测头痛频率(=0.255)。对于RCPH,手术显示出优于药物治疗的效果。本研究提供了新的证据,即术前CT扫描应被视为分析鼻腔亚型的非侵入性金标准,因为它们会显著影响手术成功率,泡状鼻甲与较差的疼痛缓解相关。应开展更大规模的研究来验证这些发现,以优化RCPH的管理。