脂筏：公海上的异质性。
Lipid rafts: heterogeneity on the high seas.
作者信息
Pike Linda J
机构信息
Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics, 660 So. Euclid Avenue, Box 8231, St. Louis, MO 63110, USA.
出版信息
Biochem J. 2004 Mar 1;378(Pt 2):281-92. doi: 10.1042/BJ20031672.
Abstract
Lipid rafts are membrane microdomains that are enriched in cholesterol and glycosphingolipids. They have been implicated in processes as diverse as signal transduction, endocytosis and cholesterol trafficking. Recent evidence suggests that this diversity of function is accompanied by a diversity in the composition of lipid rafts. The rafts in cells appear to be heterogeneous both in terms of their protein and their lipid content, and can be localized to different regions of the cell. This review summarizes the data supporting the concept of heterogeneity among lipid rafts and outlines the evidence for cross-talk between raft components. Based on differences in the ways in which proteins interact with rafts, the Induced-Fit Model of Raft Heterogeneity is proposed to explain the establishment and maintenance of heterogeneity within raft populations.
摘要
脂筏是富含胆固醇和糖鞘脂的膜微区。它们参与了多种过程，如信号转导、内吞作用和胆固醇运输。最近的证据表明，这种功能多样性伴随着脂筏组成的多样性。细胞中的脂筏在蛋白质和脂质含量方面似乎都是异质的，并且可以定位于细胞的不同区域。这篇综述总结了支持脂筏异质性概念的数据，并概述了脂筏成分之间相互作用的证据。基于蛋白质与脂筏相互作用方式的差异，提出了脂筏异质性的诱导契合模型来解释脂筏群体中异质性的建立和维持。
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