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A finding of highly selective synthetic inhibitor of plasma kallikrein; its action to bradykinin generation, intrinsic coagulation and experimental DIC.

作者信息

Okamoto S, Wanaka K, Hijikata-Okunomiya A, Okada Y, Katsuura Y

机构信息

Kobe Research Projects on Thrombosis and Haemostasis, Japan.

出版信息

Agents Actions Suppl. 1992;38 ( Pt 1):198-205. doi: 10.1007/978-3-0348-7321-5_26.

DOI:10.1007/978-3-0348-7321-5_26
PMID:1466271
Abstract

We found a novel and highly selective synthetic inhibitor of plasma kallikrein (PK), called PKSI-527; the Ki value was 0.81 microM. PKSI-527 inhibited the bradykinin (BK) generation induced by kaolin and prolonged partial thromboplastin time (PTT). PKSI-527 prevented the decrease of fibrinogen (Fg) levels due to i.v. injection of ellagic acid in mice and ameliorated the endotoxin (ET)-induced DIC in rats.

摘要

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