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Evaluation of a PCR-based universal heteroduplex generator assay as a tool for rapid detection of multidrug-resistant Mycobacterium tuberculosis in Peru.评估基于聚合酶链反应的通用异源双链体生成检测法作为秘鲁快速检测耐多药结核分枝杆菌工具的效果。
J Clin Microbiol. 2003 Dec;41(12):5774-7. doi: 10.1128/JCM.41.12.5774-5777.2003.
2
[Validation of the PCR-based universal heteroduplex generator assay for identification of rifampicin-resistant and multiresistant Mycobacterium tuberculosis in Lima, Peru].
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Evaluation of a polymerase chain reaction-based universal heteroduplex generator assay for direct detection of rifampin susceptibility of Mycobacterium tuberculosis from sputum specimens.基于聚合酶链反应的通用异源双链体生成检测法用于直接检测痰标本中结核分枝杆菌对利福平的敏感性评估。
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本文引用的文献

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Improved detection of Mycobacterium tuberculosis in Peruvian children by use of a heminested IS6110 polymerase chain reaction assay.采用半巢式IS6110聚合酶链反应分析法提高秘鲁儿童结核分枝杆菌的检测率
Clin Infect Dis. 2003 Jan 1;36(1):16-23. doi: 10.1086/344900. Epub 2002 Dec 13.
2
Performance of the microscopic observation drug susceptibility assay in drug susceptibility testing for Mycobacterium tuberculosis.显微镜观察药物敏感性试验在结核分枝杆菌药物敏感性检测中的性能
J Clin Microbiol. 2002 Dec;40(12):4750-2. doi: 10.1128/JCM.40.12.4750-4752.2002.
3
Multidrug-resistant tuberculosis and HIV infection.
Ann N Y Acad Sci. 2001 Dec;953:192-8. doi: 10.1111/j.1749-6632.2001.tb11377.x.
4
DOTS and DOTS-plus: not the only answer.直接观察短程治疗（DOTS）及其强化版：并非唯一答案。
Ann N Y Acad Sci. 2001 Dec;953:165-84. doi: 10.1111/j.1749-6632.2001.tb11375.x.
5
Molecular techniques in the diagnosis of Mycobacterium tuberculosis and the detection of drug resistance.用于诊断结核分枝杆菌及检测耐药性的分子技术
Ann N Y Acad Sci. 2001 Dec;953:138-45. doi: 10.1111/j.1749-6632.2001.tb11371.x.
6
Molecular detection of antimicrobial resistance.抗菌药物耐药性的分子检测
Clin Microbiol Rev. 2001 Oct;14(4):836-71, table of contents. doi: 10.1128/CMR.14.4.836-871.2001.
7
Molecular diagnosis of mycobacteria.分枝杆菌的分子诊断
Clin Chem. 2001 May;47(5):809-14.
8
The value of fluorescence microscopy of auramine stained sputum smears for the diagnosis of pulmonary tuberculosis.金胺染色痰涂片荧光显微镜检查对肺结核诊断的价值。
Southeast Asian J Trop Med Public Health. 1998 Dec;29(4):860-3.
9
Rapid, efficient detection and drug susceptibility testing of Mycobacterium tuberculosis in sputum by microscopic observation of broth cultures. The Tuberculosis Working Group in Peru.通过对肉汤培养物的显微镜观察对痰液中的结核分枝杆菌进行快速、高效检测及药敏试验。秘鲁结核病工作组。
J Clin Microbiol. 2000 Mar;38(3):1203-8. doi: 10.1128/JCM.38.3.1203-1208.2000.
10
Using treatment failure under effective directly observed short-course chemotherapy programs to identify patients with multidrug-resistant tuberculosis.在有效的直接观察短程化疗方案下，利用治疗失败情况来识别耐多药结核病患者。
Int J Tuberc Lung Dis. 2000 Feb;4(2):108-14.

评估基于聚合酶链反应的通用异源双链体生成检测法作为秘鲁快速检测耐多药结核分枝杆菌工具的效果。

Evaluation of a PCR-based universal heteroduplex generator assay as a tool for rapid detection of multidrug-resistant Mycobacterium tuberculosis in Peru.

作者信息

Mayta Holger, Gilman Robert H, Arenas Fanny, Valencia Teresa, Caviedes Luz, Montenegro Sonia H, Ticona Eduardo, Ortiz Jaime, Chumpitaz Rosa, Evans Carlton A, Williams Diana L

机构信息

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.

出版信息

J Clin Microbiol. 2003 Dec;41(12):5774-7. doi: 10.1128/JCM.41.12.5774-5777.2003.

DOI:10.1128/JCM.41.12.5774-5777.2003
PMID:14662980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC308991/
Abstract

Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and reliability to detect and identify drug-resistant Mycobacterium tuberculosis in a developing country where tuberculosis is highly endemic.

摘要

耐多药结核病在全球范围内正成为一个日益严重的健康问题，在发展中国家尤为如此。PCR-UHG-Rif检测法可检测与利福平耐药相关的rpoB基因内的突变，该检测法在结核病高度流行的一个发展中国家，就其检测和鉴定耐药结核分枝杆菌的能力及可靠性进行了评估。