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[术后疼痛管理:硬膜外镇痛]

[Postoperative pain management: epidural analgesia].

作者信息

Gianferrari P, Voltolina M, Clara M E, Marzullo A, Campra D

机构信息

Azienda Ospedaliera, San Giovanni Battista, Torino, UOA Anestesia e Rianimazione 9, Italy.

出版信息

Minerva Chir. 2003 Dec;58(6):857-60.

Abstract

BACKGROUND

Epidural analgesia is one of the most effective regimens for postoperative pain relief after abdominal surgery. The use of epidural analgesia in high risk patients has been associated with significant decrease in surgical stress response, in cardiac and pulmonary morbidity, in recovery of gastrointestinal function and in thromboembolic events. The aim of this paper is to describe pain relief, side effects and recovery of gastrointestinal function during epidural analgesia.

METHODS

During the period January 1999 to September 2001, 590 patients undergoing elective major abdominal surgery received epidural analgesia. Epidural catheters were inserted at T8-T9 (upper abdominal surgery) or T9-T11 (lower abdominal surgery) and ropivacaine 0.5% ml 7-12 combined with sufentanil 30 microg or with morphine 2 mg was injected. General anesthesia was induced and a continuous epidural infusion of ropivacaine 0.5% 5-10 ml/h was begun. Postoperatively, continuous epidural administration of ropivacaine 0.2% plus sufentanil 0.5 microg/ml or ropivacaine 0.2% plus morphine 0.02 mg/ml was continued. Data on the quality of analgesia, recovery of gastrointestinal function and all side effects were recorded for 4 days.

RESULTS

Resting and incident pain scores were <4 and <5; 20% of patients received a rescue dose; the incidence of nausea was 6%, pruritus 5%; all patients also recovered from postoperative ileus.

CONCLUSIONS

Continuous epidural analgesia resulted in good pain relief, provided the best balance of analgesia and side effects and improved postoperative outcome.

摘要

背景

硬膜外镇痛是腹部手术后最有效的术后疼痛缓解方案之一。在高危患者中使用硬膜外镇痛与手术应激反应、心肺并发症、胃肠功能恢复及血栓栓塞事件的显著减少相关。本文旨在描述硬膜外镇痛期间的疼痛缓解、副作用及胃肠功能恢复情况。

方法

在1999年1月至2001年9月期间,590例行择期腹部大手术的患者接受了硬膜外镇痛。在T8 - T9(上腹部手术)或T9 - T11(下腹部手术)置入硬膜外导管,并注入0.5%罗哌卡因7 - 12毫升联合舒芬太尼30微克或吗啡2毫克。诱导全身麻醉后,开始以每小时5 - 10毫升的速度持续硬膜外输注0.5%罗哌卡因。术后,继续持续硬膜外给予0.2%罗哌卡因加0.5微克/毫升舒芬太尼或0.2%罗哌卡因加0.02毫克/毫升吗啡。记录4天内镇痛质量、胃肠功能恢复及所有副作用的数据。

结果

静息和突发疼痛评分分别<4和<5;20%的患者接受了补救剂量;恶心发生率为6%,瘙痒发生率为5%;所有患者术后肠梗阻也均恢复。

结论

持续硬膜外镇痛可实现良好的疼痛缓解,在镇痛和副作用之间提供了最佳平衡,并改善了术后结局。

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