Bovenzi Francesco, De Luca Leonardo, Signore Nicola, Fusco Filomena, de Luca Italo
Department of Cardiology, Azienda Policlinico, Bari, Italy.
Ital Heart J. 2003 Oct;4(10):728-30.
Hemophilia B is a severe inherited coagulopathy caused by mutations in the gene that encodes factor IX. Surgical and invasive procedures in patients suffering from this congenital disease are to be considered as being at high risk of hemorrhage. We describe a case of a patient with unstable angina who suffered from severe hemophilia B, pre-treated with plasma purified factor IX concentrate and not on antithrombotic therapy, in whom the use of abciximab induced the complete lysis of an acute thrombus complicating the implantation of a stent on the left anterior descending coronary artery.
血友病B是一种严重的遗传性凝血病，由编码凝血因子IX的基因突变引起。患有这种先天性疾病的患者进行外科手术和侵入性操作时，被认为有很高的出血风险。我们描述了一例不稳定型心绞痛患者，该患者患有严重的血友病B，术前使用血浆纯化的凝血因子IX浓缩物治疗且未接受抗血栓治疗，在该患者中，使用阿昔单抗导致急性血栓完全溶解，该血栓使左前降支冠状动脉支架植入术出现并发症。
