Prakasam A, Sethupathy S, Pugalendi K V
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India.
Pharmazie. 2003 Nov;58(11):828-32.
The hypolipidaemic effect of an aqueous extract of Casearia esculenta root, an indigenous antidiabetic medicine popularly used in rural South India was investigated. Administration of the extract of C. esculenta (200 and 300 mg/kg body wt.) for 45 days resulted in significant reduction in serum and tissue cholesterol, phospholipids, free fatty acids and triglycerides in streptozotocin (STZ) diabetic rats. In addition to that, significant (p < 0.05) decrease in high density lipoprotein (HDL) whereas significant increase (p < 0.05) in low density lipoprotein (LDL) and very low density lipoprotein (VLDL) were observed in STZ diabetic rats, which was normalized after 45 days of C. esculenta root extract treatment. The root extract at dose of 300 mg/kg body wt. showed much significant hypolipidaemic effects than the dose of 200 mg/kg body weight.
对南印度农村地区广泛使用的一种本土抗糖尿病药物——刺蒴麻根水提取物的降血脂作用进行了研究。给链脲佐菌素（STZ）诱导的糖尿病大鼠连续45天给予刺蒴麻提取物（200和300毫克/千克体重），可显著降低血清和组织中的胆固醇、磷脂、游离脂肪酸和甘油三酯水平。此外，STZ糖尿病大鼠的高密度脂蛋白（HDL）显著降低（p<0.05），而低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）显著升高（p<0.05），经刺蒴麻根提取物治疗45天后这些指标恢复正常。300毫克/千克体重剂量的根提取物比200毫克/千克体重剂量显示出更显著的降血脂作用。
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