Decreasing the diabetic complication by vanadyl(VO)2+/vitamin B 6 complex in alloxan-induced diabetic mice.

The scope of this work was to synthesize a novel bifunctionalized vanadyl(VO)(2+)/vitamin B 6 complex. The diabetic therapeutic efficacy of the new complex was investigated in alloxan-induced diabetic mice. The results suggested that vanadyl(VO)(2+)/vit B6 complex has an anti-diabetic potency, improved the lipid profile and liver and kidney functions. The new complex possesses an antioxidant activity. The current results support the therapeutic potentiality of vanadyl(VO)(2+)/vitamin B 6 complex for the management of diabetes.