Lowe Franklin C, Gilbert Scott M, Kahane Hillel
Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York, USA.
Urology. 2003 Dec;62(6):1045-9. doi: 10.1016/s0090-4295(03)00782-9.
To analyze the age-specific detection rate of prostate cancer diagnosed from 324,684 biopsies submitted to a single laboratory and to assess the degree of prostate cancer in younger men. The advent of prostate-specific antigen (PSA) testing and increased prostate cancer screening has led to increased evaluations for prostate cancer. The initial stage and age at presentation in prostate cancer has shifted.
From 1995 through 2001, all prostate biopsies submitted to the laboratory were reviewed and analyzed for the diagnosis of prostate cancer, cancer detection rate, and age at diagnosis.
The overall detection rate of prostate cancer increased by 15% from 29% to 34% for all biopsies submitted during the study period. For the age group 50 to 59 years, a 45% increase occurred in the detection of prostate cancer from a baseline of approximately 11% in 1995 to greater than 16% in 2001. For the age group 70 to 79 years, the detection of prostate cancer decreased from a baseline of 41% in 1995 to 36% in 2001.
The increase in prostate cancer diagnosis among younger men in the United States has been significant. The increase is likely multifactorial and may be attributable to the impact of PSA and prostate cancer screening efforts. This has led to a greater number of younger men undergoing evaluation for prostate cancer. Thus, a heightened awareness regarding the diagnosis of prostate cancer among younger men is needed.
分析提交至单个实验室的324,684份活检样本中前列腺癌的年龄特异性检出率，并评估年轻男性前列腺癌的严重程度。前列腺特异性抗原（PSA）检测的出现以及前列腺癌筛查的增加导致了对前列腺癌评估的增加。前列腺癌的初始阶段和就诊年龄已经发生了变化。
对1995年至2001年间提交至该实验室的所有前列腺活检样本进行回顾和分析，以诊断前列腺癌、癌症检出率和诊断年龄。
在研究期间提交的所有活检样本中，前列腺癌的总体检出率从29%上升至34%，增长了15%。对于50至59岁年龄组，前列腺癌的检出率从1995年约11%的基线水平增长至2001年的超过16%，增长了45%。对于70至79岁年龄组，前列腺癌的检出率从1995年41%的基线水平降至2001年的36%。
美国年轻男性中前列腺癌诊断的增加幅度显著。这种增加可能是多因素的，可能归因于PSA的影响和前列腺癌筛查工作。这导致更多年轻男性接受前列腺癌评估。因此，需要提高对年轻男性前列腺癌诊断的认识。
