Park K G, Blessing K, Kernohan N M
Department of Surgery, Aberdeen University, Foresterhill, Scotland.
Ann Surg. 1992 Dec;216(6):692-5. doi: 10.1097/00000658-199212000-00012.
The incidence, treatment, and survival of subungual malignant melanomas in Scotland is reviewed from the Scottish Melanoma Group database. Between 1979 and 1989, 100 cases of subungual melanoma were identified (2.8% of all malignant melanomas in Scotland). The tumors tended to be locally advanced at the time of presentation (mean Breslow depth, 4.7 mm +/- 3.0 mm), and this is reflected in an overall 5-year survival of 41%. There was no difference in the survival of patients treated with local/proximal interphalangeal (PIP) joint amputation compared with those having more proximal amputations. Because nearly 70% of these tumors arose on the thumb or hallux, it is concluded that, provided adequate clearance could be obtained, less radical excision should be performed for these lesions to maintain maximum function.
通过苏格兰黑色素瘤研究小组数据库，对苏格兰甲下恶性黑色素瘤的发病率、治疗方法及生存率进行了回顾。1979年至1989年间，共确诊100例甲下黑色素瘤（占苏格兰所有恶性黑色素瘤的2.8%）。这些肿瘤在初诊时往往已局部进展（平均 Breslow深度为4.7毫米±3.0毫米），这反映在总体5年生存率为41%。与接受更近端截肢术的患者相比，接受局部/近端指间（PIP）关节截肢术的患者生存率无差异。由于这些肿瘤近70%发生于拇指或拇趾，因此得出结论，若能获得足够的切缘，对这些病变应采用较保守的切除术以保留最大功能。
