日本人群中家族性前列腺癌的全基因组连锁分析。
Genomewide linkage analysis of familial prostate cancer in the Japanese population.
作者信息
Matsui Hiroshi, Suzuki Kazuhiro, Ohtake Nobuaki, Nakata Seiji, Takeuchi Toshiyuki, Yamanaka Hidetoshi, Inoue Ituro
机构信息
Division of Genetic Diagnosis, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Department of Urology, Gunma University Graduate School of Medicine, Gunma University, Maebashi, Japan.
出版信息
J Hum Genet. 2004;49(1):9-15. doi: 10.1007/s10038-003-0099-y. Epub 2003 Dec 10.
Prostate cancer (PC) is one of the most common causes of cancer mortality in Western countries, and familial aggregation of PC is well known. Multiple PC susceptibility loci have been reported in Western countries, but attempts to confirm the loci in independent data sets have proven to be inconsistent. We performed a genomewide linkage analysis with 53 affected sib pairs to identify genetic loci related to PC in a Japanese population. Two linkage analyses, GENEHUNTER-PLUS and SIBPAL, were applied and detected nominal statistical significance of linkage to PC at chromosome 1p and 8p, which were reported as being loci for PC in Caucasians. The best evidence of linkage was detected near D8S550 on 8p23 (maximum Zlr=2.25, P=0.037), and the second-best evidence of linkage was observed near D1S2667 on 1p36 (maximum Zlr=2.24, P=0.034). This is the first genetic mapping of PC in Japanese, and the results suggest that susceptibilities to PC lie close to D8S550 on 8p23 and D1S2667 on 1p36.
前列腺癌（PC）是西方国家癌症死亡的最常见原因之一，且PC的家族聚集现象众所周知。西方国家已报道了多个PC易感基因座，但在独立数据集中对这些基因座进行验证的尝试结果并不一致。我们对53对患病同胞对进行了全基因组连锁分析，以在日本人群中鉴定与PC相关的基因座。应用了两种连锁分析方法，即GENEHUNTER-PLUS和SIBPAL，并在1号染色体p臂和8号染色体p臂上检测到与PC连锁的名义统计学显著性，这些区域在白种人中被报道为PC的基因座。在8号染色体p23区的D8S550附近检测到最强的连锁证据（最大Zlr=2.25，P=0.037），在1号染色体p36区的D1S2667附近观察到次强的连锁证据（最大Zlr=2.24，P=0.034）。这是日本人群中首次对PC进行基因定位，结果表明PC易感性与8号染色体p23区的D8S550和1号染色体p36区的D1S2667附近区域相关。
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