胰岛素样生长因子及其结合蛋白在葡萄糖稳态中的作用。
The role of the insulin-like growth factors and their binding proteins in glucose homeostasis.
作者信息
Murphy Liam J
机构信息
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
出版信息
Exp Diabesity Res. 2003 Oct-Dec;4(4):213-24. doi: 10.1155/EDR.2003.213.
The insulin like growth factors (IGF-I and -II) are structurally and functionally related to insulin. While insulin is a key regulator of glucose homeostasis over the short term, emerging evidence suggests that the IGFs are involved in the longer term glucose homeostasis, possibly by modulating insulin sensitivity. Unlike insulin, the IGFs are present in most biological fluids as complexes with high affinity binding proteins, the insulin-like growth factor binding proteins (IGFBPs). The IGFBPs regulate the bioavailability of the IGFs. Of the six IGFBPs identified there is evidence from studies in transgenic mice that both IGFBP-1 and IGFBP-3 may have a role in glucose regulation.
胰岛素样生长因子（IGF-I和-II）在结构和功能上与胰岛素相关。虽然胰岛素是短期内葡萄糖稳态的关键调节因子，但新出现的证据表明，IGF可能参与长期的葡萄糖稳态，可能是通过调节胰岛素敏感性来实现的。与胰岛素不同，IGF在大多数生物体液中以与高亲和力结合蛋白——胰岛素样生长因子结合蛋白（IGFBP）形成的复合物形式存在。IGFBP调节IGF的生物利用度。在已鉴定的六种IGFBP中，转基因小鼠研究的证据表明，IGFBP-1和IGFBP-3可能在葡萄糖调节中发挥作用。
Zotero 插件